a tool for identifying drug-targetable redox-active disulphides

Glycosylated lysosomal membrane protein

Intramolecular

Cysteine 245 and cysteine 328

A redox-regulated disulphide may form within Glycosylated lysosomal membrane protein between cysteines 245 and 328.

Details

Redox score ?

80

PDB code

Structure name

crystal structure of glycosylated lysosomal membrane protein (glmp) luminal domain bound to a fab fragment

Structure deposition date

2019-02-12

Thiol separation (Å)

2

Half-sphere exposure sum ?

70

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

245

Residue number B

328

Peptide name

Glycosylated lysosomal membrane protein

Ligandability

Cysteine 245 of Glycosylated lysosomal membrane protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Glycosylated lysosomal membrane protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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