ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Choline transporter-like protein 1

Intermolecular
Cysteine 485 and cysteine 485
Intramolecular
Cysteine 485 and cysteine 488
Cysteine 488 and cysteine 492
Cysteine 484 and cysteine 488
Cysteine 484 and cysteine 485
Cysteine 482 and cysteine 485
Cysteine 549 and cysteine 576
Cysteine 482 and cysteine 484
A redox-regulated disulphide may form between two units of Choline transporter-like protein 1 at cysteines 485 and 485.

Details

Redox score ?
64
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide A name
Choline transporter-like protein 1
Peptide B name
Choline transporter-like protein 1
Peptide A accession
Q8WWI5
Peptide B accession
Q8WWI5
Peptide A residue number
485
Peptide B residue number
485

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choline transporter-like protein 1 between cysteines 485 and 488. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
38
Minimum pKa ?
10
% buried
0
Peptide accession
Q8WWI5
Residue number A
485
Residue number B
488
Peptide name
Choline transporter-like protein 1

Ligandability

Cysteine 485 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 488 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choline transporter-like protein 1 between cysteines 488 and 492. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
35
Minimum pKa ?
9
% buried
4
Peptide accession
Q8WWI5
Residue number A
488
Residue number B
492
Peptide name
Choline transporter-like protein 1

Ligandability

Cysteine 488 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 492 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choline transporter-like protein 1 between cysteines 484 and 488. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
0
Peptide accession
Q8WWI5
Residue number A
484
Residue number B
488
Peptide name
Choline transporter-like protein 1

Ligandability

Cysteine 484 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 488 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choline transporter-like protein 1 between cysteines 484 and 485. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
Q8WWI5
Residue number A
484
Residue number B
485
Peptide name
Choline transporter-like protein 1

Ligandability

Cysteine 484 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 485 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choline transporter-like protein 1 between cysteines 482 and 485. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
Q8WWI5
Residue number A
482
Residue number B
485
Peptide name
Choline transporter-like protein 1

Ligandability

Cysteine 482 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 485 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choline transporter-like protein 1 between cysteines 549 and 576. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
0
Peptide accession
Q8WWI5
Residue number A
549
Residue number B
576
Peptide name
Choline transporter-like protein 1

Ligandability

Cysteine 549 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 576 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Choline transporter-like protein 1 between cysteines 482 and 484. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7wwb
Structure name
choline transporter-like protein 1
Structure deposition date
2022-02-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide accession
Q8WWI5
Residue number A
482
Residue number B
484
Peptide name
Choline transporter-like protein 1

Ligandability

Cysteine 482 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 484 of Choline transporter-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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