ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mannose-binding protein A

Intramolecular
Cysteine 145 and cysteine 234
Cysteine 212 and cysteine 226
A redox-regulated disulphide may form within Mannose-binding protein A between cysteines 145 and 234 (128 and 217 respectively in this structure).

Details

Redox score ?
82
PDB code
1buu
Structure name
one ho3+ form of rat mannose-binding protein a
Structure deposition date
1998-09-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19999
Residue number A
145
Residue number B
234
Peptide name
Mannose-binding protein A

Ligandability

Cysteine 145 of Mannose-binding protein A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Mannose-binding protein A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-binding protein A between cysteines 212 and 226 (195 and 209 respectively in this structure).

Details

Redox score ?
81
PDB code
1kwv
Structure name
rat mannose binding protein a complexed with a-me-glcnac
Structure deposition date
2002-01-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19999
Residue number A
212
Residue number B
226
Peptide name
Mannose-binding protein A

Ligandability

Cysteine 212 of Mannose-binding protein A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Mannose-binding protein A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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