ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-1 family member 10

Intramolecular
Cysteine 37 and cysteine 38
Cysteine 43 and cysteine 67
A redox-regulated disulphide may form within Interleukin-1 family member 10 between cysteines 37 and 38. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5bow
Structure name
crystal structure of il-38
Structure deposition date
2015-05-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q8WWZ1
Residue number A
37
Residue number B
38
Peptide name
Interleukin-1 family member 10

Ligandability

Cysteine 37 of Interleukin-1 family member 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 38 of Interleukin-1 family member 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 family member 10 between cysteines 43 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5bow
Structure name
crystal structure of il-38
Structure deposition date
2015-05-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
68
Peptide accession
Q8WWZ1
Residue number A
43
Residue number B
67
Peptide name
Interleukin-1 family member 10

Ligandability

Cysteine 43 of Interleukin-1 family member 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Interleukin-1 family member 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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