ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Palladin

Intramolecular
Cysteine 1047 and cysteine 1111
Cysteine 1047 and cysteine 1083
A redox-regulated disulphide may form within Palladin between cysteines 1047 and 1111 (29 and 93 respectively in this structure).

Details

Redox score ?
67
PDB code
2lqr
Structure name
nmr structure of ig3 domain of palladin
Structure deposition date
2012-03-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
41
Peptide accession
Q9ET54
Residue number A
1047
Residue number B
1111
Peptide name
Palladin

Ligandability

Cysteine 1047 of Palladin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1111 of Palladin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Palladin between cysteines 1047 and 1083 (29 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2lqr
Structure name
nmr structure of ig3 domain of palladin
Structure deposition date
2012-03-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
56
Peptide accession
Q9ET54
Residue number A
1047
Residue number B
1083
Peptide name
Palladin

Ligandability

Cysteine 1047 of Palladin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1083 of Palladin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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