ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Intramolecular
Cysteine 84 and cysteine 88
Cysteine 84 and cysteine 91
Cysteine 88 and cysteine 91
A redox-regulated disulphide may form within S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 between cysteines 84 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6q2q
Structure name
crystal structure of mouse viperin bound to uridine triphosphate and s-adenosylhomocysteine
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
94
Peptide accession
Q8CBB9
Residue number A
84
Residue number B
88
Peptide name
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Ligandability

Cysteine 84 of S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 between cysteines 84 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5vsm
Structure name
crystal structure of viperin with bound [4fe-4s] cluster, 5'- deoxyadenosine, and l-methionine
Structure deposition date
2017-05-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
100
Peptide accession
Q8CBB9
Residue number A
84
Residue number B
91
Peptide name
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Ligandability

Cysteine 84 of S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 between cysteines 88 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5vsl
Structure name
crystal structure of viperin with bound [4fe-4s] cluster and s- adenosylhomocysteine (sah)
Structure deposition date
2017-05-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
100
Peptide accession
Q8CBB9
Residue number A
88
Residue number B
91
Peptide name
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Ligandability

Cysteine 88 of S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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