ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nesprin-2

Intramolecular
Cysteine 1432 and cysteine 1509
Cysteine 1526 and cysteine 1530
A redox-regulated disulphide may form within Nesprin-2 between cysteines 1432 and 1509.

Details

Redox score ?
76
PDB code
6xf1
Structure name
nesprin-2g(aa1425-1649)-fhod1(aa1-339) complex, h
Structure deposition date
2020-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
41
Peptide accession
Q8WXH0
Residue number A
1432
Residue number B
1509
Peptide name
Nesprin-2

Ligandability

Cysteine 1432 of Nesprin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1509 of Nesprin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nesprin-2 between cysteines 1526 and 1530. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6xf1
Structure name
nesprin-2g(aa1425-1649)-fhod1(aa1-339) complex, h
Structure deposition date
2020-06-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
56
Peptide accession
Q8WXH0
Residue number A
1526
Residue number B
1530
Peptide name
Nesprin-2

Ligandability

Cysteine 1526 of Nesprin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1530 of Nesprin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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