ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Suppressor of cytokine signaling 4

Intermolecular
Cysteine 393 and cysteine 112 of Elongin-C
Intramolecular
Cysteine 398 and cysteine 400
A redox-regulated disulphide may form between cysteine 393 of Suppressor of cytokine signaling 4 and cysteine 112 of Elongin-C. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2izv
Structure name
crystal structure of socs-4 in complex with elongin-b and elongin-c at 2
Structure deposition date
2006-07-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
13
% buried
94
Peptide A name
Suppressor of cytokine signaling 4
Peptide B name
Elongin-C
Peptide A accession
Q8WXH5
Peptide B accession
Q15369
Peptide A residue number
393
Peptide B residue number
112

Ligandability

Cysteine 393 of Suppressor of cytokine signaling 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Elongin-C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Suppressor of cytokine signaling 4 between cysteines 398 and 400. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2izv
Structure name
crystal structure of socs-4 in complex with elongin-b and elongin-c at 2
Structure deposition date
2006-07-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
68
Peptide accession
Q8WXH5
Residue number A
398
Residue number B
400
Peptide name
Suppressor of cytokine signaling 4

Ligandability

Cysteine 398 of Suppressor of cytokine signaling 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 400 of Suppressor of cytokine signaling 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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