ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage-dependent calcium channel gamma-8 subunit

Intramolecular
Cysteine 52 and cysteine 91
Cysteine 90 and cysteine 100
Cysteine 91 and cysteine 100
Cysteine 90 and cysteine 91
Cysteine 52 and cysteine 100
Cysteine 52 and cysteine 90
A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-8 subunit between cysteines 52 and 91.

Details

Redox score ?
86
PDB code
7oce
Structure name
resting state glua1/a2 ampa receptor in complex with tarp gamma 8 and cnih2 (lbd-tmd)
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHW5
Residue number A
52
Residue number B
91
Peptide name
Voltage-dependent calcium channel gamma-8 subunit

Ligandability

Cysteine 52 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-8 subunit between cysteines 90 and 100.

Details

Redox score ?
83
PDB code
7ldd
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHW2
Residue number A
90
Residue number B
100
Peptide name
Voltage-dependent calcium channel gamma-8 subunit

Ligandability

Cysteine 90 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-8 subunit between cysteines 91 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6qkc
Structure name
glua1/2 in complex with auxiliary subunit gamma-8
Structure deposition date
2019-01-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
nan
Peptide accession
Q8VHW5
Residue number A
91
Residue number B
100
Peptide name
Voltage-dependent calcium channel gamma-8 subunit

Ligandability

Cysteine 91 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-8 subunit between cysteines 90 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7ocd
Structure name
resting state glua1/a2 heterotetramer in complex with auxiliary subunit tarp gamma 8 (lbd-tmd)
Structure deposition date
2021-04-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHW5
Residue number A
90
Residue number B
91
Peptide name
Voltage-dependent calcium channel gamma-8 subunit

Ligandability

Cysteine 90 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-8 subunit between cysteines 52 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7ocd
Structure name
resting state glua1/a2 heterotetramer in complex with auxiliary subunit tarp gamma 8 (lbd-tmd)
Structure deposition date
2021-04-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHW5
Residue number A
52
Residue number B
100
Peptide name
Voltage-dependent calcium channel gamma-8 subunit

Ligandability

Cysteine 52 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-8 subunit between cysteines 52 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7ocf
Structure name
active state glua1/a2 ampa receptor in complex with tarp gamma 8 and cnih2 (lbd-tmd)
Structure deposition date
2021-04-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHW5
Residue number A
52
Residue number B
90
Peptide name
Voltage-dependent calcium channel gamma-8 subunit

Ligandability

Cysteine 52 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Voltage-dependent calcium channel gamma-8 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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