ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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E3 ubiquitin-protein ligase MYLIP

Intermolecular
Cysteine 400 and cysteine 400
Intramolecular
Cysteine 3 and cysteine 26
Cysteine 111 and cysteine 144
Cysteine 26 and cysteine 31
A redox-regulated disulphide may form between two units of E3 ubiquitin-protein ligase MYLIP at cysteines 400 and 400. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
2yho
Structure name
the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor
Structure deposition date
2011-05-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
51
Peptide A name
E3 ubiquitin-protein ligase MYLIP
Peptide B name
E3 ubiquitin-protein ligase MYLIP
Peptide A accession
Q8WY64
Peptide B accession
Q8WY64
Peptide A residue number
400
Peptide B residue number
400

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MYLIP between cysteines 3 and 26.

Details

Redox score ?
72
PDB code
6qly
Structure name
idol ferm domain
Structure deposition date
2019-02-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
70
Peptide accession
Q8WY64
Residue number A
3
Residue number B
26
Peptide name
E3 ubiquitin-protein ligase MYLIP

Ligandability

Cysteine 3 of E3 ubiquitin-protein ligase MYLIP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 26 of E3 ubiquitin-protein ligase MYLIP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MYLIP between cysteines 111 and 144.

Details

Redox score ?
67
PDB code
6qly
Structure name
idol ferm domain
Structure deposition date
2019-02-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
26
Peptide accession
Q8WY64
Residue number A
111
Residue number B
144
Peptide name
E3 ubiquitin-protein ligase MYLIP

Ligandability

Cysteine 111 of E3 ubiquitin-protein ligase MYLIP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of E3 ubiquitin-protein ligase MYLIP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MYLIP between cysteines 26 and 31. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6qly
Structure name
idol ferm domain
Structure deposition date
2019-02-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
74
Peptide accession
Q8WY64
Residue number A
26
Residue number B
31
Peptide name
E3 ubiquitin-protein ligase MYLIP

Ligandability

Cysteine 26 of E3 ubiquitin-protein ligase MYLIP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 31 of E3 ubiquitin-protein ligase MYLIP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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