ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-catenin-like protein 1

Intramolecular
Cysteine 318 and cysteine 320
Cysteine 408 and cysteine 497
A redox-regulated disulphide may form within Beta-catenin-like protein 1 between cysteines 318 and 320. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4mfu
Structure name
crystal structure of human ctnnbl1(residues 77~563)
Structure deposition date
2013-08-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
Q8WYA6
Residue number A
318
Residue number B
320
Peptide name
Beta-catenin-like protein 1

Ligandability

Cysteine 318 of Beta-catenin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of Beta-catenin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-catenin-like protein 1 between cysteines 408 and 497. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
4mfu
Structure name
crystal structure of human ctnnbl1(residues 77~563)
Structure deposition date
2013-08-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
100
Peptide accession
Q8WYA6
Residue number A
408
Residue number B
497
Peptide name
Beta-catenin-like protein 1

Ligandability

Cysteine 408 of Beta-catenin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 497 of Beta-catenin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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