ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Inhibitor of growth protein 5

Intramolecular
Cysteine 207 and cysteine 232
Cysteine 229 and cysteine 232
Cysteine 202 and cysteine 232
Cysteine 189 and cysteine 216
Cysteine 189 and cysteine 191
Cysteine 202 and cysteine 207
Cysteine 207 and cysteine 229
Cysteine 191 and cysteine 216
Cysteine 202 and cysteine 229
Cysteine 189 and cysteine 229
A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 207 and 232.

Details

Redox score ?
91
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
14
Peptide accession
Q8WYH8
Residue number A
207
Residue number B
232
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 207 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 229 and 232.

Details

Redox score ?
90
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
8
Peptide accession
Q8WYH8
Residue number A
229
Residue number B
232
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 229 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 202 and 232.

Details

Redox score ?
89
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
8
Peptide accession
Q8WYH8
Residue number A
202
Residue number B
232
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 202 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 189 and 216.

Details

Redox score ?
86
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
15
Peptide accession
Q8WYH8
Residue number A
189
Residue number B
216
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 189 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 189 and 191.

Details

Redox score ?
86
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
14
Peptide accession
Q8WYH8
Residue number A
189
Residue number B
191
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 189 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 202 and 207.

Details

Redox score ?
85
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
16
Peptide accession
Q8WYH8
Residue number A
202
Residue number B
207
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 202 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 207 and 229.

Details

Redox score ?
83
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
24
Peptide accession
Q8WYH8
Residue number A
207
Residue number B
229
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 207 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 191 and 216.

Details

Redox score ?
80
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
2
Peptide accession
Q8WYH8
Residue number A
191
Residue number B
216
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 191 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 202 and 229.

Details

Redox score ?
75
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
28
Peptide accession
Q8WYH8
Residue number A
202
Residue number B
229
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 202 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inhibitor of growth protein 5 between cysteines 189 and 229. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3c6w
Structure name
crystal structure of the ing5 phd finger in complex with h3k4me3 peptide
Structure deposition date
2008-02-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
24
Peptide accession
Q8WYH8
Residue number A
189
Residue number B
229
Peptide name
Inhibitor of growth protein 5

Ligandability

Cysteine 189 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Inhibitor of growth protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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