ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Microprocessor complex subunit DGCR8

Intramolecular
Cysteine 657 and cysteine 666
A redox-regulated disulphide may form within Microprocessor complex subunit DGCR8 between cysteines 657 and 666.

Details

Redox score ?
62
PDB code
6v5c
Structure name
human drosha and dgcr8 in complex with primary microrna (mp/rna complex) - partially docked state
Structure deposition date
2019-12-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
25
Peptide accession
Q8WYQ5
Residue number A
657
Residue number B
666
Peptide name
Microprocessor complex subunit DGCR8

Ligandability

Cysteine 657 of Microprocessor complex subunit DGCR8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 666 of Microprocessor complex subunit DGCR8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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