Phosphoinositide 3-kinase regulatory subunit 5
Intermolecular
Cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and cysteine 120
Cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and cysteine 123
Intramolecular
Cysteine 20 and cysteine 41
Cysteine 288 and cysteine 660
Cysteine 120 and cysteine 123
7mez A 524 B 120
A redox-regulated disulphide may form between cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and cysteine 120 of Phosphoinositide 3-kinase regulatory subunit 5.
Details
Redox score ?
76
PDB code
7mez
Structure name
structure of the phosphoinositide 3-kinase p110 gamma (pik3cg) p101 (pik3r5) complex
Structure deposition date
2021-04-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
58
Peptide A name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Peptide B name
Phosphoinositide 3-kinase regulatory subunit 5
Peptide A accession
P48736
Peptide B accession
O02696
Peptide A residue number
524
Peptide B residue number
120
Ligandability
Cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 120 of Phosphoinositide 3-kinase regulatory subunit 5
7mez A 524 B 123
A redox-regulated disulphide may form between cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and cysteine 123 of Phosphoinositide 3-kinase regulatory subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7mez
Structure name
structure of the phosphoinositide 3-kinase p110 gamma (pik3cg) p101 (pik3r5) complex
Structure deposition date
2021-04-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
70
Peptide A name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Peptide B name
Phosphoinositide 3-kinase regulatory subunit 5
Peptide A accession
P48736
Peptide B accession
O02696
Peptide A residue number
524
Peptide B residue number
123
Ligandability
Cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 123 of Phosphoinositide 3-kinase regulatory subunit 5
7mez B 20 B 41
A redox-regulated disulphide may form within Phosphoinositide 3-kinase regulatory subunit 5 between cysteines 20 and 41.
Details
Redox score ?
61
PDB code
7mez
Structure name
structure of the phosphoinositide 3-kinase p110 gamma (pik3cg) p101 (pik3r5) complex
Structure deposition date
2021-04-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
36
Peptide accession
O02696
Residue number A
20
Residue number B
41
Peptide name
Phosphoinositide 3-kinase regulatory subunit 5
Ligandability
Cysteine 20 of Phosphoinositide 3-kinase regulatory subunit 5
Cysteine 41 of Phosphoinositide 3-kinase regulatory subunit 5
7mez B 288 B 660
A redox-regulated disulphide may form within Phosphoinositide 3-kinase regulatory subunit 5 between cysteines 288 and 660. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7mez
Structure name
structure of the phosphoinositide 3-kinase p110 gamma (pik3cg) p101 (pik3r5) complex
Structure deposition date
2021-04-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
92
Peptide accession
O02696
Residue number A
288
Residue number B
660
Peptide name
Phosphoinositide 3-kinase regulatory subunit 5
Ligandability
Cysteine 288 of Phosphoinositide 3-kinase regulatory subunit 5
Cysteine 660 of Phosphoinositide 3-kinase regulatory subunit 5
7mez B 120 B 123
A redox-regulated disulphide may form within Phosphoinositide 3-kinase regulatory subunit 5 between cysteines 120 and 123. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7mez
Structure name
structure of the phosphoinositide 3-kinase p110 gamma (pik3cg) p101 (pik3r5) complex
Structure deposition date
2021-04-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
12
% buried
88
Peptide accession
O02696
Residue number A
120
Residue number B
123
Peptide name
Phosphoinositide 3-kinase regulatory subunit 5
Ligandability
Cysteine 120 of Phosphoinositide 3-kinase regulatory subunit 5
Cysteine 123 of Phosphoinositide 3-kinase regulatory subunit 5
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