ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Intramolecular
Cysteine 562 and cysteine 596
Cysteine 269 and cysteine 279
Cysteine 421 and cysteine 490
Cysteine 254 and cysteine 281
Cysteine 254 and cysteine 269
Cysteine 279 and cysteine 281
Cysteine 269 and cysteine 281
Cysteine 254 and cysteine 279
A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 562 and 596.

Details

Redox score ?
86
PDB code
5ggi
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase in complex with mn, udp and mannosyl- peptide
Structure deposition date
2016-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WZA1
Residue number A
562
Residue number B
596
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 562 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 596 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 269 and 279.

Details

Redox score ?
85
PDB code
5ggi
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase in complex with mn, udp and mannosyl- peptide
Structure deposition date
2016-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WZA1
Residue number A
269
Residue number B
279
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 269 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 421 and 490.

Details

Redox score ?
75
PDB code
5ggg
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase form i
Structure deposition date
2016-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WZA1
Residue number A
421
Residue number B
490
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 421 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 490 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 254 and 281.

Details

Redox score ?
66
PDB code
5ggf
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase form ii
Structure deposition date
2016-06-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
18
Peptide accession
Q8WZA1
Residue number A
254
Residue number B
281
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 254 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 254 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5ggf
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase form ii
Structure deposition date
2016-06-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WZA1
Residue number A
254
Residue number B
269
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 254 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 279 and 281. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5ggf
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase form ii
Structure deposition date
2016-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WZA1
Residue number A
279
Residue number B
281
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 279 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 269 and 281. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5ggf
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase form ii
Structure deposition date
2016-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WZA1
Residue number A
269
Residue number B
281
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 269 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 between cysteines 254 and 279. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5ggf
Structure name
crystal structure of human protein o-mannose beta-1,2-n- acetylglucosaminyltransferase form ii
Structure deposition date
2016-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WZA1
Residue number A
254
Residue number B
279
Peptide name
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Ligandability

Cysteine 254 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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