Rap guanine nucleotide exchange factor 4
Intramolecular
Cysteine 105 and cysteine 413
Cysteine 235 and cysteine 236
Cysteine 676 and cysteine 743
Cysteine 18 and cysteine 56
Cysteine 56 and cysteine 58
Cysteine 832 and cysteine 834
4f7z A 105 A 395
A redox-regulated disulphide may form within Rap guanine nucleotide exchange factor 4 between cysteines 105 and 413 (105 and 395 respectively in this structure).
Details
Redox score ?
68
PDB code
4f7z
Structure name
conformational dynamics of exchange protein directly activated by camp
Structure deposition date
2012-05-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
Q9EQZ6
Residue number A
105
Residue number B
413
Peptide name
Rap guanine nucleotide exchange factor 4
Ligandability
Cysteine 105 of Rap guanine nucleotide exchange factor 4
Cysteine 413 of Rap guanine nucleotide exchange factor 4
4f7z A 217 A 218
A redox-regulated disulphide may form within Rap guanine nucleotide exchange factor 4 between cysteines 235 and 236 (217 and 218 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4f7z
Structure name
conformational dynamics of exchange protein directly activated by camp
Structure deposition date
2012-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
78
Peptide accession
Q9EQZ6
Residue number A
235
Residue number B
236
Peptide name
Rap guanine nucleotide exchange factor 4
Ligandability
Cysteine 235 of Rap guanine nucleotide exchange factor 4
Cysteine 236 of Rap guanine nucleotide exchange factor 4
4mgi E 658 E 725
A redox-regulated disulphide may form within Rap guanine nucleotide exchange factor 4 between cysteines 676 and 743 (658 and 725 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4mgi
Structure name
selective activation of epac1 and epac2
Structure deposition date
2013-08-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
35
Peptide accession
Q9EQZ6
Residue number A
676
Residue number B
743
Peptide name
Rap guanine nucleotide exchange factor 4
Ligandability
Cysteine 676 of Rap guanine nucleotide exchange factor 4
Cysteine 743 of Rap guanine nucleotide exchange factor 4
1o7f A 18 A 56
A redox-regulated disulphide may form within Rap guanine nucleotide exchange factor 4 between cysteines 18 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
1o7f
Structure name
crystal structure of the regulatory domain of epac2
Structure deposition date
2002-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
40
Peptide accession
Q9Z1P0
Residue number A
18
Residue number B
56
Peptide name
Rap guanine nucleotide exchange factor 4
Ligandability
Cysteine 18 of Rap guanine nucleotide exchange factor 4
Cysteine 56 of Rap guanine nucleotide exchange factor 4
4f7z A 56 A 58
A redox-regulated disulphide may form within Rap guanine nucleotide exchange factor 4 between cysteines 56 and 58. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
4f7z
Structure name
conformational dynamics of exchange protein directly activated by camp
Structure deposition date
2012-05-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
76
Peptide accession
Q9EQZ6
Residue number A
56
Residue number B
58
Peptide name
Rap guanine nucleotide exchange factor 4
Ligandability
Cysteine 56 of Rap guanine nucleotide exchange factor 4
Cysteine 58 of Rap guanine nucleotide exchange factor 4
4mgk E 814 E 816
A redox-regulated disulphide may form within Rap guanine nucleotide exchange factor 4 between cysteines 832 and 834 (814 and 816 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
4mgk
Structure name
selective activation of epac1 and epac2
Structure deposition date
2013-08-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
71
Peptide accession
Q9EQZ6
Residue number A
832
Residue number B
834
Peptide name
Rap guanine nucleotide exchange factor 4
Ligandability
Cysteine 832 of Rap guanine nucleotide exchange factor 4
Cysteine 834 of Rap guanine nucleotide exchange factor 4
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