ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ighg protein

Intramolecular
Cysteine 393 and cysteine 115
Cysteine 164 and cysteine 219
A redox-regulated disulphide may form within Ighg protein between cysteines 393 and 115 (22 and 92 respectively in this structure).

Details

Redox score ?
80
PDB code
2gk0
Structure name
structure of catalytic elimination antibody 13g5 from a twinned crystal in space group c2
Structure deposition date
2006-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q91Z05
Residue number A
393
Residue number B
115
Peptide name
Ighg protein

Ligandability

Cysteine 393 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ighg protein between cysteines 164 and 219 (142 and 208 respectively in this structure).

Details

Redox score ?
79
PDB code
2gk0
Structure name
structure of catalytic elimination antibody 13g5 from a twinned crystal in space group c2
Structure deposition date
2006-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q91Z05
Residue number A
164
Residue number B
219
Peptide name
Ighg protein

Ligandability

Cysteine 164 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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