ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pterin-mimicking anti-idiotope kappa chain variable region

Intramolecular
Cysteine 23 and cysteine 88
Cysteine 134 and cysteine 23
A redox-regulated disulphide may form within Pterin-mimicking anti-idiotope kappa chain variable region between cysteines 23 and 88.

Details

Redox score ?
80
PDB code
1jgl
Structure name
crystal structure of immunoglobulin fab fragment complexed with 17-beta-estradiol
Structure deposition date
2001-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q920E6
Residue number A
23
Residue number B
88
Peptide name
Pterin-mimicking anti-idiotope kappa chain variable region

Ligandability

Cysteine 23 of Pterin-mimicking anti-idiotope kappa chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Pterin-mimicking anti-idiotope kappa chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pterin-mimicking anti-idiotope kappa chain variable region between cysteines 134 and 23 (134 and 194 respectively in this structure).

Details

Redox score ?
nan
PDB code
1jgl
Structure name
crystal structure of immunoglobulin fab fragment complexed with 17-beta-estradiol
Structure deposition date
2001-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q920E6
Residue number A
134
Residue number B
23
Peptide name
Pterin-mimicking anti-idiotope kappa chain variable region

Ligandability

Cysteine 134 of Pterin-mimicking anti-idiotope kappa chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 23 of Pterin-mimicking anti-idiotope kappa chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 194 has been assigned to correct residue.
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