ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA damage-binding protein 2

Intramolecular
Cysteine 48 and cysteine 52 L
Cysteine 253 and cysteine 254
A redox-regulated disulphide may form within DNA damage-binding protein 2 between cysteines 48 and 52.

Details

Redox score ?
89
PDB code
4e54
Structure name
damaged dna induced uv-damaged dna-binding protein (uv-ddb) dimerization and its roles in chromatinized dna repair
Structure deposition date
2012-03-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
33
Minimum pKa ?
8
% buried
0
Peptide accession
Q92466
Residue number A
48
Residue number B
52
Peptide name
DNA damage-binding protein 2

Ligandability

Cysteine 48 of DNA damage-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 52 of DNA damage-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA damage-binding protein 2 between cysteines 253 and 254. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4e5z
Structure name
damaged dna induced uv-damaged dna-binding protein (uv-ddb) dimerization and its roles in chromatinized dna repair
Structure deposition date
2012-03-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
64
Peptide accession
Q92466
Residue number A
253
Residue number B
254
Peptide name
DNA damage-binding protein 2

Ligandability

Cysteine 253 of DNA damage-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of DNA damage-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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