ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Acid sphingomyelinase-like phosphodiesterase 3b

Intramolecular
Cysteine 405 and cysteine 409
Cysteine 415 and cysteine 428
Cysteine 45 and cysteine 64
A redox-regulated disulphide may form within Acid sphingomyelinase-like phosphodiesterase 3b between cysteines 405 and 409.

Details

Redox score ?
88
PDB code
5kas
Structure name
murine acid sphingomyelinase-like phosphodiesterase 3b (smpdl3b) with phosphocholine
Structure deposition date
2016-06-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P58242
Residue number A
405
Residue number B
409
Peptide name
Acid sphingomyelinase-like phosphodiesterase 3b

Ligandability

Cysteine 405 of Acid sphingomyelinase-like phosphodiesterase 3b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 409 of Acid sphingomyelinase-like phosphodiesterase 3b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acid sphingomyelinase-like phosphodiesterase 3b between cysteines 415 and 428.

Details

Redox score ?
81
PDB code
5kas
Structure name
murine acid sphingomyelinase-like phosphodiesterase 3b (smpdl3b) with phosphocholine
Structure deposition date
2016-06-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P58242
Residue number A
415
Residue number B
428
Peptide name
Acid sphingomyelinase-like phosphodiesterase 3b

Ligandability

Cysteine 415 of Acid sphingomyelinase-like phosphodiesterase 3b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 428 of Acid sphingomyelinase-like phosphodiesterase 3b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acid sphingomyelinase-like phosphodiesterase 3b between cysteines 45 and 64.

Details

Redox score ?
81
PDB code
5kar
Structure name
murine acid sphingomyelinase-like phosphodiesterase 3b (smpdl3b)
Structure deposition date
2016-06-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
P58242
Residue number A
45
Residue number B
64
Peptide name
Acid sphingomyelinase-like phosphodiesterase 3b

Ligandability

Cysteine 45 of Acid sphingomyelinase-like phosphodiesterase 3b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Acid sphingomyelinase-like phosphodiesterase 3b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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