ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Piezo-type mechanosensitive ion channel component 1

Intramolecular
Cysteine 881 and cysteine 1059
Cysteine 1243 and cysteine 1271
Cysteine 2437 and cysteine 2441
Cysteine 994 and cysteine 1103
Cysteine 1146 and cysteine 1535
Cysteine 994 and cysteine 1037
Cysteine 1232 and cysteine 1253
Cysteine 1188 and cysteine 1286
A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 881 and 1059.

Details

Redox score ?
89
PDB code
6b3r
Structure name
structure of the mechanosensitive channel piezo1
Structure deposition date
2017-09-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
E2JF22
Residue number A
881
Residue number B
1059
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 881 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1059 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 1243 and 1271.

Details

Redox score ?
85
PDB code
7wlt
Structure name
the curved structure of mpiezo1 in lipid bilayer
Structure deposition date
2022-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
E2JF22
Residue number A
1243
Residue number B
1271
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 1243 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1271 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 2437 and 2441.

Details

Redox score ?
74
PDB code
7wlu
Structure name
the flattened structure of mpiezo1 in lipid bilayer
Structure deposition date
2022-01-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
E2JF22
Residue number A
2437
Residue number B
2441
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 2437 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2441 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 994 and 1103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7wlt
Structure name
the curved structure of mpiezo1 in lipid bilayer
Structure deposition date
2022-01-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
80
Peptide accession
E2JF22
Residue number A
994
Residue number B
1103
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 994 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1103 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 1146 and 1535 (1146 and 1511 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6lqi
Structure name
cryo-em structure of the mouse piezo1 isoform piezo1
Structure deposition date
2020-01-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
66
Peptide accession
E2JF22
Residue number A
1146
Residue number B
1535
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 1146 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1535 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 994 and 1037. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7wlt
Structure name
the curved structure of mpiezo1 in lipid bilayer
Structure deposition date
2022-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
89
Peptide accession
E2JF22
Residue number A
994
Residue number B
1037
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 994 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1037 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 1232 and 1253. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6b3r
Structure name
structure of the mechanosensitive channel piezo1
Structure deposition date
2017-09-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
64
Peptide accession
E2JF22
Residue number A
1232
Residue number B
1253
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 1232 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1253 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Piezo-type mechanosensitive ion channel component 1 between cysteines 1188 and 1286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6b3r
Structure name
structure of the mechanosensitive channel piezo1
Structure deposition date
2017-09-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
94
Peptide accession
E2JF22
Residue number A
1188
Residue number B
1286
Peptide name
Piezo-type mechanosensitive ion channel component 1

Ligandability

Cysteine 1188 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1286 of Piezo-type mechanosensitive ion channel component 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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