Tribbles homolog 2

Intramolecular

A redox-regulated disulphide may form within Tribbles homolog 2 between cysteines 104 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7upm

Structure name

tribbles (trib2) pseudokinase bound to nanobody nb4

Structure deposition date

2022-04-15

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q92519

Residue number A

104

Residue number B

106

Peptide name

Tribbles homolog 2

Ligandability

Cysteine 104 of Tribbles homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Tribbles homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tribbles homolog 2 between cysteines 106 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7upm

Structure name

tribbles (trib2) pseudokinase bound to nanobody nb4

Structure deposition date

2022-04-15

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q92519

Residue number A

106

Residue number B

166

Peptide name

Tribbles homolog 2

Ligandability

Cysteine 106 of Tribbles homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of Tribbles homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tribbles homolog 2 between cysteines 104 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?