C-C motif chemokine 17
Intermolecular
Cysteine 38 of Evasin P974 and cysteine 73
Cysteine 33 and cysteine 33
Cysteine 73 and cysteine 33
Cysteine 34 and cysteine 33
Cysteine 38 of Evasin P974 and cysteine 34
Cysteine 57 and cysteine 33
Intramolecular
Cysteine 34 and cysteine 73
Cysteine 34 and cysteine 57
Cysteine 57 and cysteine 73
7s4n A 9 B 50
A redox-regulated disulphide may form between cysteine 38 of Evasin P974 and cysteine 73 of C-C motif chemokine 17 (9 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7s4n
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl17
Structure deposition date
2021-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Evasin P974
Peptide B name
C-C motif chemokine 17
Peptide A accession
A0A023FDY8
Peptide B accession
Q92583
Peptide A residue number
38
Peptide B residue number
73
Ligandability
Cysteine 38 of Evasin P974
Cysteine 73 of C-C motif chemokine 17
1nr4 A 10 B 10
A redox-regulated disulphide may form between two units of C-C motif chemokine 17 at cysteines 33 and 33 (10 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
1nr4
Structure name
high resolution crystal structures of thymus and activation-regulated chemokine
Structure deposition date
2003-01-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 17
Peptide B name
C-C motif chemokine 17
Peptide A accession
Q92583
Peptide B accession
Q92583
Peptide A residue number
33
Peptide B residue number
33
Ligandability
1nr4 G 50 H 10
A redox-regulated disulphide may form between two units of C-C motif chemokine 17 at cysteines 73 and 33 (50 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
1nr4
Structure name
high resolution crystal structures of thymus and activation-regulated chemokine
Structure deposition date
2003-01-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 17
Peptide B name
C-C motif chemokine 17
Peptide A accession
Q92583
Peptide B accession
Q92583
Peptide A residue number
73
Peptide B residue number
33
Ligandability
Cysteine 73 of C-C motif chemokine 17
Cysteine 33 of C-C motif chemokine 17
1nr4 G 11 H 10
A redox-regulated disulphide may form between two units of C-C motif chemokine 17 at cysteines 34 and 33 (11 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
1nr4
Structure name
high resolution crystal structures of thymus and activation-regulated chemokine
Structure deposition date
2003-01-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 17
Peptide B name
C-C motif chemokine 17
Peptide A accession
Q92583
Peptide B accession
Q92583
Peptide A residue number
34
Peptide B residue number
33
Ligandability
Cysteine 34 of C-C motif chemokine 17
Cysteine 33 of C-C motif chemokine 17
7s4n C 9 D 11
A redox-regulated disulphide may form between cysteine 38 of Evasin P974 and cysteine 34 of C-C motif chemokine 17 (9 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7s4n
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl17
Structure deposition date
2021-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Evasin P974
Peptide B name
C-C motif chemokine 17
Peptide A accession
A0A023FDY8
Peptide B accession
Q92583
Peptide A residue number
38
Peptide B residue number
34
Ligandability
Cysteine 38 of Evasin P974
Cysteine 34 of C-C motif chemokine 17
1nr4 A 34 B 10
A redox-regulated disulphide may form between two units of C-C motif chemokine 17 at cysteines 57 and 33 (34 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
1nr4
Structure name
high resolution crystal structures of thymus and activation-regulated chemokine
Structure deposition date
2003-01-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 17
Peptide B name
C-C motif chemokine 17
Peptide A accession
Q92583
Peptide B accession
Q92583
Peptide A residue number
57
Peptide B residue number
33
Ligandability
Cysteine 57 of C-C motif chemokine 17
Cysteine 33 of C-C motif chemokine 17
7s4n D 11 D 50
A redox-regulated disulphide may form within C-C motif chemokine 17 between cysteines 34 and 73 (11 and 50 respectively in this structure).
Details
Redox score ?
80
PDB code
7s4n
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl17
Structure deposition date
2021-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92583
Residue number A
34
Residue number B
73
Peptide name
C-C motif chemokine 17
Ligandability
Cysteine 34 of C-C motif chemokine 17
Cysteine 73 of C-C motif chemokine 17
1nr4 F 11 F 34
A redox-regulated disulphide may form within C-C motif chemokine 17 between cysteines 34 and 57 (11 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
1nr4
Structure name
high resolution crystal structures of thymus and activation-regulated chemokine
Structure deposition date
2003-01-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92583
Residue number A
34
Residue number B
57
Peptide name
C-C motif chemokine 17
Ligandability
Cysteine 34 of C-C motif chemokine 17
Cysteine 57 of C-C motif chemokine 17
7s4n D 34 D 50
A redox-regulated disulphide may form within C-C motif chemokine 17 between cysteines 57 and 73 (34 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7s4n
Structure name
crystal structure of the tick evasin eva-p974 complexed to human chemokine ccl17
Structure deposition date
2021-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92583
Residue number A
57
Residue number B
73
Peptide name
C-C motif chemokine 17
Ligandability
Cysteine 57 of C-C motif chemokine 17
Cysteine 73 of C-C motif chemokine 17
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