Mastermind-like protein 1
Intermolecular
Cysteine 100 of Recombining binding protein suppressor of hairless and cysteine 63
Cysteine 397 of Recombining binding protein suppressor of hairless and cysteine 37
Intramolecular
Cysteine 1101 and cysteine 30
Cysteine 30 and cysteine 1134
Cysteine 6 and cysteine 1058
Cysteine 6 and cysteine 1061
Cysteine 1025 and cysteine 1028
Cysteine 1098 and cysteine 30
Cysteine 1028 and cysteine 1061
2f8x C 86 M 63
A redox-regulated disulphide may form between cysteine 100 of Recombining binding protein suppressor of hairless and cysteine 63 of Mastermind-like protein 1 (86 and 63 respectively in this structure).
Details
Redox score ?
76
PDB code
2f8x
Structure name
crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence
Structure deposition date
2005-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
63
Peptide A name
Recombining binding protein suppressor of hairless
Peptide B name
Mastermind-like protein 1
Peptide A accession
Q06330
Peptide B accession
Q92585
Peptide A residue number
100
Peptide B residue number
63
Ligandability
Cysteine 100 of Recombining binding protein suppressor of hairless
Cysteine 63 of Mastermind-like protein 1
2f8x C 383 M 37
A redox-regulated disulphide may form between cysteine 397 of Recombining binding protein suppressor of hairless and cysteine 37 of Mastermind-like protein 1 (383 and 37 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
2f8x
Structure name
crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence
Structure deposition date
2005-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
92
Peptide A name
Recombining binding protein suppressor of hairless
Peptide B name
Mastermind-like protein 1
Peptide A accession
Q06330
Peptide B accession
Q92585
Peptide A residue number
397
Peptide B residue number
37
Ligandability
Cysteine 397 of Recombining binding protein suppressor of hairless
Cysteine 37 of Mastermind-like protein 1
6smv A 1101 A 1131
A redox-regulated disulphide may form within Mastermind-like protein 1 between cysteines 1101 and 30 (1101 and 1131 respectively in this structure).
Details
Redox score ?
74
PDB code
6smv
Structure name
structure of hpv49 e6 protein in complex with maml1 lxxll motif
Structure deposition date
2019-08-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
45
Peptide accession
Q92585
Residue number A
1101
Residue number B
30
Peptide name
Mastermind-like protein 1
Ligandability
Cysteine 1101 of Mastermind-like protein 1
Cysteine 30 of Mastermind-like protein 1
Cysteine 1101 in protein A could not be asigned to a Uniprot residue.
6smv A 1131 A 1134
A redox-regulated disulphide may form within Mastermind-like protein 1 between cysteines 30 and 1134 (1131 and 1134 respectively in this structure).
Details
Redox score ?
nan
PDB code
6smv
Structure name
structure of hpv49 e6 protein in complex with maml1 lxxll motif
Structure deposition date
2019-08-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
30
Peptide accession
Q92585
Residue number A
30
Residue number B
1134
Peptide name
Mastermind-like protein 1
Ligandability
Cysteine 30 of Mastermind-like protein 1
Cysteine 1134 of Mastermind-like protein 1
Cysteine 1134 in protein B could not be asigned to a Uniprot residue.
6smv A 1057 A 1058
A redox-regulated disulphide may form within Mastermind-like protein 1 between cysteines 6 and 1058 (1057 and 1058 respectively in this structure).
Details
Redox score ?
nan
PDB code
6smv
Structure name
structure of hpv49 e6 protein in complex with maml1 lxxll motif
Structure deposition date
2019-08-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
58
Peptide accession
Q92585
Residue number A
6
Residue number B
1058
Peptide name
Mastermind-like protein 1
Ligandability
Cysteine 6 of Mastermind-like protein 1
Cysteine 1058 of Mastermind-like protein 1
Uncertain whether structure cysteine 1057 has been assigned to correct residue.
Cysteine 1058 in protein B could not be asigned to a Uniprot residue.
6smv A 1057 A 1061
A redox-regulated disulphide may form within Mastermind-like protein 1 between cysteines 6 and 1061 (1057 and 1061 respectively in this structure).
Details
Redox score ?
nan
PDB code
6smv
Structure name
structure of hpv49 e6 protein in complex with maml1 lxxll motif
Structure deposition date
2019-08-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
62
Peptide accession
Q92585
Residue number A
6
Residue number B
1061
Peptide name
Mastermind-like protein 1
Ligandability
Cysteine 6 of Mastermind-like protein 1
Cysteine 1061 of Mastermind-like protein 1
Uncertain whether structure cysteine 1057 has been assigned to correct residue.
Cysteine 1061 in protein B could not be asigned to a Uniprot residue.
6smv A 1025 A 1028
A redox-regulated disulphide may form within Mastermind-like protein 1 between cysteines 1025 and 1028.
Details
Redox score ?
nan
PDB code
6smv
Structure name
structure of hpv49 e6 protein in complex with maml1 lxxll motif
Structure deposition date
2019-08-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
3
% buried
30
Peptide accession
Q92585
Residue number A
1025
Residue number B
1028
Peptide name
Mastermind-like protein 1
Ligandability
Cysteine 1025 of Mastermind-like protein 1
Cysteine 1028 of Mastermind-like protein 1
Cysteine 1025 in protein A could not be asigned to a Uniprot residue.
Cysteine 1028 in protein B could not be asigned to a Uniprot residue.
6smv A 1098 A 1131
A redox-regulated disulphide may form within Mastermind-like protein 1 between cysteines 1098 and 30 (1098 and 1131 respectively in this structure).
Details
Redox score ?
nan
PDB code
6smv
Structure name
structure of hpv49 e6 protein in complex with maml1 lxxll motif
Structure deposition date
2019-08-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
3
% buried
47
Peptide accession
Q92585
Residue number A
1098
Residue number B
30
Peptide name
Mastermind-like protein 1
Ligandability
Cysteine 1098 of Mastermind-like protein 1
Cysteine 30 of Mastermind-like protein 1
Cysteine 1098 in protein A could not be asigned to a Uniprot residue.
6smv A 1028 A 1061
A redox-regulated disulphide may form within Mastermind-like protein 1 between cysteines 1028 and 1061.
Details
Redox score ?
nan
PDB code
6smv
Structure name
structure of hpv49 e6 protein in complex with maml1 lxxll motif
Structure deposition date
2019-08-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
20
Peptide accession
Q92585
Residue number A
1028
Residue number B
1061
Peptide name
Mastermind-like protein 1
Ligandability
Cysteine 1028 of Mastermind-like protein 1
Cysteine 1061 of Mastermind-like protein 1
Cysteine 1028 in protein A could not be asigned to a Uniprot residue.
Cysteine 1061 in protein B could not be asigned to a Uniprot residue.
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