ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dedicator of cytokinesis protein 2

Intermolecular
Cysteine 41 and cysteine 726 of Engulfment and cell motility protein 1
Intramolecular
Cysteine 451 and cysteine 453
A redox-regulated disulphide may form between cysteine 41 of Dedicator of cytokinesis protein 2 and cysteine 726 of Engulfment and cell motility protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6tgb
Structure name
cryoem structure of the binary dock2-elmo1 complex
Structure deposition date
2019-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Dedicator of cytokinesis protein 2
Peptide B name
Engulfment and cell motility protein 1
Peptide A accession
Q92608
Peptide B accession
Q92556
Peptide A residue number
41
Peptide B residue number
726

Ligandability

Cysteine 41 of Dedicator of cytokinesis protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 726 of Engulfment and cell motility protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dedicator of cytokinesis protein 2 between cysteines 451 and 453.

Details

Redox score ?
71
PDB code
6tgc
Structure name
cryoem structure of the ternary dock2-elmo1-rac1 complex
Structure deposition date
2019-11-15
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92608
Residue number A
451
Residue number B
453
Peptide name
Dedicator of cytokinesis protein 2

Ligandability

Cysteine 451 of Dedicator of cytokinesis protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Dedicator of cytokinesis protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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