Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Intramolecular
Cysteine 826 and cysteine 881
Cysteine 826 and cysteine 884
Cysteine 915 and cysteine 929
Cysteine 721 and cysteine 724
Cysteine 721 and cysteine 750
Cysteine 929 and cysteine 932
Cysteine 912 and cysteine 915
Cysteine 721 and cysteine 747
Cysteine 891 and cysteine 923
Cysteine 912 and cysteine 929
More...Cysteine 891 and cysteine 894
Cysteine 915 and cysteine 932
Cysteine 747 and cysteine 750
Cysteine 724 and cysteine 747
Cysteine 724 and cysteine 750
Cysteine 894 and cysteine 923
Cysteine 881 and cysteine 884
Cysteine 909 and cysteine 918
Cysteine 912 and cysteine 932
Cysteine 747 and cysteine 749
Cysteine 749 and cysteine 750
Cysteine 721 and cysteine 749
Cysteine 724 and cysteine 749
Cysteine 891 and cysteine 909
Cysteine 891 and cysteine 918
Cysteine 912 and cysteine 918
6wcw A 826 A 881
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 826 and 881.
Details
Redox score ?
91
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
4
% buried
38
Peptide accession
Q92622
Residue number A
826
Residue number B
881
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 826 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 881 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 826 A 884
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 826 and 884.
Details
Redox score ?
89
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
4
% buried
56
Peptide accession
Q92622
Residue number A
826
Residue number B
884
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 826 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 884 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 915 A 929
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 915 and 929.
Details
Redox score ?
89
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
28
Peptide accession
Q92622
Residue number A
915
Residue number B
929
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 915 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 929 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 721 A 724
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 721 and 724.
Details
Redox score ?
88
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
5
% buried
15
Peptide accession
Q92622
Residue number A
721
Residue number B
724
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 721 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 724 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 721 A 750
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 721 and 750.
Details
Redox score ?
87
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
21
Peptide accession
Q92622
Residue number A
721
Residue number B
750
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 721 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 750 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 929 A 932
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 929 and 932.
Details
Redox score ?
86
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
18
Peptide accession
Q92622
Residue number A
929
Residue number B
932
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 929 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 932 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 912 A 915
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 912 and 915.
Details
Redox score ?
85
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
21
Peptide accession
Q92622
Residue number A
912
Residue number B
915
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 912 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 915 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 721 A 747
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 721 and 747.
Details
Redox score ?
85
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
5
% buried
24
Peptide accession
Q92622
Residue number A
721
Residue number B
747
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 721 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 747 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 891 A 923
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 891 and 923.
Details
Redox score ?
84
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
25
Peptide accession
Q92622
Residue number A
891
Residue number B
923
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 891 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 923 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 912 A 929
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 912 and 929.
Details
Redox score ?
84
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
26
Peptide accession
Q92622
Residue number A
912
Residue number B
929
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 912 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 929 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 891 A 894
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 891 and 894.
Details
Redox score ?
82
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
28
Peptide accession
Q92622
Residue number A
891
Residue number B
894
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 891 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 894 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 915 A 932
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 915 and 932.
Details
Redox score ?
82
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
13
Peptide accession
Q92622
Residue number A
915
Residue number B
932
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 915 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 932 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 747 A 750
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 747 and 750.
Details
Redox score ?
82
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
15
Peptide accession
Q92622
Residue number A
747
Residue number B
750
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 747 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 750 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 724 A 747
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 724 and 747.
Details
Redox score ?
80
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
9
Peptide accession
Q92622
Residue number A
724
Residue number B
747
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 724 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 747 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 724 A 750
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 724 and 750.
Details
Redox score ?
79
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
6
Peptide accession
Q92622
Residue number A
724
Residue number B
750
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 724 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 750 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 894 A 923
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 894 and 923.
Details
Redox score ?
79
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
14
Peptide accession
Q92622
Residue number A
894
Residue number B
923
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 894 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 923 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 881 A 884
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 881 and 884.
Details
Redox score ?
77
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
48
Peptide accession
Q92622
Residue number A
881
Residue number B
884
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 881 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 884 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 909 A 918
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 909 and 918.
Details
Redox score ?
76
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
74
Peptide accession
Q92622
Residue number A
909
Residue number B
918
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 909 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 918 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 912 A 932
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 912 and 932.
Details
Redox score ?
74
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
12
Peptide accession
Q92622
Residue number A
912
Residue number B
932
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 912 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 932 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 747 A 749
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 747 and 749.
Details
Redox score ?
69
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
7
% buried
9
Peptide accession
Q92622
Residue number A
747
Residue number B
749
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 747 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 749 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 749 A 750
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 749 and 750. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
6
Peptide accession
Q92622
Residue number A
749
Residue number B
750
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 749 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 750 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 721 A 749
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 721 and 749. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
5
% buried
15
Peptide accession
Q92622
Residue number A
721
Residue number B
749
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 721 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 749 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 724 A 749
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 724 and 749. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
Q92622
Residue number A
724
Residue number B
749
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 724 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 749 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 891 A 909
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 891 and 909. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
52
Peptide accession
Q92622
Residue number A
891
Residue number B
909
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 891 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 909 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 891 A 918
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 891 and 918. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
6
% buried
62
Peptide accession
Q92622
Residue number A
891
Residue number B
918
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 891 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 918 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
6wcw A 912 A 918
A redox-regulated disulphide may form within Run domain Beclin-1-interacting and cysteine-rich domain-containing protein between cysteines 912 and 918. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6wcw
Structure name
structure of human rubicon rh domain in complex with gtp-bound rab7
Structure deposition date
2020-03-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
52
Peptide accession
Q92622
Residue number A
912
Residue number B
918
Peptide name
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Ligandability
Cysteine 912 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Cysteine 918 of Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
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