ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dual specificity tyrosine-phosphorylation-regulated kinase 2

Intramolecular
Cysteine 347 and cysteine 373
Cysteine 410 and cysteine 515
A redox-regulated disulphide may form within Dual specificity tyrosine-phosphorylation-regulated kinase 2 between cysteines 347 and 373.

Details

Redox score ?
69
PDB code
7dg4
Structure name
the co-crystal structure of dyrk2 with a small molecule inhibitor 6
Structure deposition date
2020-11-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
81
Peptide accession
Q92630
Residue number A
347
Residue number B
373
Peptide name
Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligandability

Cysteine 347 of Dual specificity tyrosine-phosphorylation-regulated kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Dual specificity tyrosine-phosphorylation-regulated kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual specificity tyrosine-phosphorylation-regulated kinase 2 between cysteines 410 and 515. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7dhc
Structure name
the co-crystal structure of dyrk2 with a small molecule inhibitor 10
Structure deposition date
2020-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
Q92630
Residue number A
410
Residue number B
515
Peptide name
Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligandability

Cysteine 410 of Dual specificity tyrosine-phosphorylation-regulated kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 515 of Dual specificity tyrosine-phosphorylation-regulated kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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