ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysophosphatidic acid receptor 1

Intramolecular
Cysteine 284 and cysteine 287
Cysteine 24 and cysteine 190
Cysteine 188 and cysteine 195
Cysteine 283 and cysteine 284
Cysteine 188 and cysteine 190
Cysteine 190 and cysteine 195
Cysteine 283 and cysteine 287
A redox-regulated disulphide may form within Lysophosphatidic acid receptor 1 between cysteines 284 and 287.

Details

Redox score ?
88
PDB code
7td0
Structure name
lysophosphatidic acid receptor 1-gi complex bound to lpa
Structure deposition date
2021-12-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92633
Residue number A
284
Residue number B
287
Peptide name
Lysophosphatidic acid receptor 1

Ligandability

Cysteine 284 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 287 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid receptor 1 between cysteines 24 and 190.

Details

Redox score ?
87
PDB code
7td1
Structure name
lysophosphatidic acid receptor 1-gi complex bound to lpa, state a
Structure deposition date
2021-12-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92633
Residue number A
24
Residue number B
190
Peptide name
Lysophosphatidic acid receptor 1

Ligandability

Cysteine 24 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid receptor 1 between cysteines 188 and 195.

Details

Redox score ?
85
PDB code
7td2
Structure name
lysophosphatidic acid receptor 1-gi complex bound to lpa, state a
Structure deposition date
2021-12-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92633
Residue number A
188
Residue number B
195
Peptide name
Lysophosphatidic acid receptor 1

Ligandability

Cysteine 188 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid receptor 1 between cysteines 283 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7td1
Structure name
lysophosphatidic acid receptor 1-gi complex bound to lpa, state a
Structure deposition date
2021-12-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
35
Minimum pKa ?
9
% buried
nan
Peptide accession
Q92633
Residue number A
283
Residue number B
284
Peptide name
Lysophosphatidic acid receptor 1

Ligandability

Cysteine 283 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid receptor 1 between cysteines 188 and 190. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7td0
Structure name
lysophosphatidic acid receptor 1-gi complex bound to lpa
Structure deposition date
2021-12-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92633
Residue number A
188
Residue number B
190
Peptide name
Lysophosphatidic acid receptor 1

Ligandability

Cysteine 188 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid receptor 1 between cysteines 190 and 195. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7td0
Structure name
lysophosphatidic acid receptor 1-gi complex bound to lpa
Structure deposition date
2021-12-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92633
Residue number A
190
Residue number B
195
Peptide name
Lysophosphatidic acid receptor 1

Ligandability

Cysteine 190 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid receptor 1 between cysteines 283 and 287. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7td1
Structure name
lysophosphatidic acid receptor 1-gi complex bound to lpa, state a
Structure deposition date
2021-12-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
nan
Peptide accession
Q92633
Residue number A
283
Residue number B
287
Peptide name
Lysophosphatidic acid receptor 1

Ligandability

Cysteine 283 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 287 of Lysophosphatidic acid receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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