ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GPI-anchor transamidase

Intermolecular
Cysteine 182 of GPI transamidase component PIG-T and cysteine 92
Intramolecular
Cysteine 275 and cysteine 280
A redox-regulated disulphide may form between cysteine 182 of GPI transamidase component PIG-T and cysteine 92 of GPI-anchor transamidase.

Details

Redox score ?
79
PDB code
7w72
Structure name
structure of a human glycosylphosphatidylinositol (gpi) transamidase
Structure deposition date
2021-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide A name
GPI transamidase component PIG-T
Peptide B name
GPI-anchor transamidase
Peptide A accession
Q969N2
Peptide B accession
Q92643
Peptide A residue number
182
Peptide B residue number
92

Ligandability

Cysteine 182 of GPI transamidase component PIG-T

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of GPI-anchor transamidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GPI-anchor transamidase between cysteines 275 and 280.

Details

Redox score ?
83
PDB code
7wld
Structure name
cryo-em structure of the human glycosylphosphatidylinositol transamidase complex at 2
Structure deposition date
2022-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
31
Peptide accession
Q92643
Residue number A
275
Residue number B
280
Peptide name
GPI-anchor transamidase

Ligandability

Cysteine 275 of GPI-anchor transamidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of GPI-anchor transamidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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