ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sortilin-related receptor

Intramolecular
Cysteine 716 and cysteine 752
Cysteine 677 and cysteine 736
Cysteine 625 and cysteine 660
Cysteine 684 and cysteine 699
Cysteine 643 and cysteine 675
Cysteine 643 and cysteine 736
Cysteine 467 and cysteine 473
Cysteine 675 and cysteine 736
Cysteine 675 and cysteine 677
Cysteine 643 and cysteine 677
A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 716 and 752.

Details

Redox score ?
91
PDB code
3wsy
Structure name
sorla vps10p domain in complex with its own propeptide fragment
Structure deposition date
2014-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
28
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
716
Residue number B
752
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 716 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 752 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 677 and 736.

Details

Redox score ?
88
PDB code
3wsy
Structure name
sorla vps10p domain in complex with its own propeptide fragment
Structure deposition date
2014-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
677
Residue number B
736
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 677 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 736 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 625 and 660.

Details

Redox score ?
84
PDB code
3wsz
Structure name
sorla vps10p domain in complex with abeta-derived peptide
Structure deposition date
2014-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
625
Residue number B
660
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 625 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 660 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 684 and 699.

Details

Redox score ?
83
PDB code
3wsy
Structure name
sorla vps10p domain in complex with its own propeptide fragment
Structure deposition date
2014-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
684
Residue number B
699
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 684 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 699 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 643 and 675.

Details

Redox score ?
78
PDB code
7vt0
Structure name
dimer structure of sorla
Structure deposition date
2021-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
3
Peptide accession
Q92673
Residue number A
643
Residue number B
675
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 643 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 675 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 643 and 736. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3wsy
Structure name
sorla vps10p domain in complex with its own propeptide fragment
Structure deposition date
2014-03-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
643
Residue number B
736
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 643 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 736 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 467 and 473. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7vt0
Structure name
dimer structure of sorla
Structure deposition date
2021-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
10
Peptide accession
Q92673
Residue number A
467
Residue number B
473
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 467 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 473 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 675 and 736. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3wsx
Structure name
sorla vps10p domain in ligand-free form
Structure deposition date
2014-03-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
675
Residue number B
736
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 675 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 736 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 675 and 677. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3wsy
Structure name
sorla vps10p domain in complex with its own propeptide fragment
Structure deposition date
2014-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
675
Residue number B
677
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 675 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 677 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sortilin-related receptor between cysteines 643 and 677. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3wsy
Structure name
sorla vps10p domain in complex with its own propeptide fragment
Structure deposition date
2014-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92673
Residue number A
643
Residue number B
677
Peptide name
Sortilin-related receptor

Ligandability

Cysteine 643 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 677 of Sortilin-related receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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