Centromere protein I
Intermolecular
Cysteine 152 and cysteine 550 of Centromere protein T
Intramolecular
Cysteine 450 and cysteine 451
Cysteine 198 and cysteine 202
Cysteine 400 and cysteine 450
Cysteine 400 and cysteine 451
Cysteine 604 and cysteine 650
7xho I 152 T 550
A redox-regulated disulphide may form between cysteine 152 of Centromere protein I and cysteine 550 of Centromere protein T. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7xho
Structure name
structure of human inner kinetochore ccan complex
Structure deposition date
2022-04-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
77
Peptide A name
Centromere protein I
Peptide B name
Centromere protein T
Peptide A accession
Q92674
Peptide B accession
Q96BT3
Peptide A residue number
152
Peptide B residue number
550
Ligandability
Cysteine 152 of Centromere protein I
Cysteine 550 of Centromere protein T
7r5s I 450 I 451
A redox-regulated disulphide may form within Centromere protein I between cysteines 450 and 451.
Details
Redox score ?
77
PDB code
7r5s
Structure name
structure of the human ccan bound to alpha satellite dna
Structure deposition date
2022-02-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
64
Peptide accession
Q92674
Residue number A
450
Residue number B
451
Peptide name
Centromere protein I
Ligandability
Cysteine 450 of Centromere protein I
Cysteine 451 of Centromere protein I
7pb4 I 198 I 202
A redox-regulated disulphide may form within Centromere protein I between cysteines 198 and 202.
Details
Redox score ?
74
PDB code
7pb4
Structure name
cenp-hik 3-protein complex
Structure deposition date
2021-07-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
6
% buried
72
Peptide accession
Q92674
Residue number A
198
Residue number B
202
Peptide name
Centromere protein I
Ligandability
Cysteine 198 of Centromere protein I
Cysteine 202 of Centromere protein I
7r5v I 400 I 450
A redox-regulated disulphide may form within Centromere protein I between cysteines 400 and 450.
Details
Redox score ?
62
PDB code
7r5v
Structure name
structure of the human ccan cenp-a alpha-satellite complex
Structure deposition date
2022-02-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
62
Peptide accession
Q92674
Residue number A
400
Residue number B
450
Peptide name
Centromere protein I
Ligandability
Cysteine 400 of Centromere protein I
Cysteine 450 of Centromere protein I
7qoo I 400 I 451
A redox-regulated disulphide may form within Centromere protein I between cysteines 400 and 451. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7qoo
Structure name
structure of the human inner kinetochore ccan complex
Structure deposition date
2021-12-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
12
% buried
78
Peptide accession
Q92674
Residue number A
400
Residue number B
451
Peptide name
Centromere protein I
Ligandability
Cysteine 400 of Centromere protein I
Cysteine 451 of Centromere protein I
7r5v I 604 I 650
A redox-regulated disulphide may form within Centromere protein I between cysteines 604 and 650. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7r5v
Structure name
structure of the human ccan cenp-a alpha-satellite complex
Structure deposition date
2022-02-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
80
Peptide accession
Q92674
Residue number A
604
Residue number B
650
Peptide name
Centromere protein I
Ligandability
Cysteine 604 of Centromere protein I
Cysteine 650 of Centromere protein I
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