ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Nectin-2

Intramolecular
Cysteine 174 and cysteine 229
Cysteine 54 and cysteine 131
A redox-regulated disulphide may form within Nectin-2 between cysteines 174 and 229.

Details

Redox score ?
82
PDB code
4fn0
Structure name
crystal structure of mouse nectin-2 extracellular fragment d1-d2, 2nd crystal form
Structure deposition date
2012-06-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32507
Residue number A
174
Residue number B
229
Peptide name
Nectin-2

Ligandability

Cysteine 174 of Nectin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Nectin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nectin-2 between cysteines 54 and 131.

Details

Redox score ?
81
PDB code
4fn0
Structure name
crystal structure of mouse nectin-2 extracellular fragment d1-d2, 2nd crystal form
Structure deposition date
2012-06-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32507
Residue number A
54
Residue number B
131
Peptide name
Nectin-2

Ligandability

Cysteine 54 of Nectin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Nectin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: