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Geranylgeranyl transferase type-2 subunit alpha

Intramolecular
Cysteine 331 and cysteine 340
Cysteine 371 and cysteine 384
Cysteine 132 and cysteine 145
Cysteine 246 and cysteine 260
Cysteine 246 and cysteine 247
Cysteine 331 and cysteine 342
Cysteine 256 and cysteine 302
Cysteine 340 and cysteine 342
Cysteine 247 and cysteine 342
Cysteine 516 and cysteine 546
More...
Cysteine 247 and cysteine 260
Cysteine 247 and cysteine 487
Cysteine 114 and cysteine 132
Cysteine 247 and cysteine 331
Cysteine 256 and cysteine 487
Cysteine 260 and cysteine 487
A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 331 and 340.

Details

Redox score ?
75
PDB code
1dce
Structure name
crystal structure of rab geranylgeranyltransferase from rat brain
Structure deposition date
1999-11-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
74
Peptide accession
Q08602
Residue number A
331
Residue number B
340
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 331 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 371 and 384.

Details

Redox score ?
68
PDB code
1dce
Structure name
crystal structure of rab geranylgeranyltransferase from rat brain
Structure deposition date
1999-11-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
86
Peptide accession
Q08602
Residue number A
371
Residue number B
384
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 371 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 132 and 145.

Details

Redox score ?
68
PDB code
3dsu
Structure name
crystal structure of rabggtase(delta lrr; delta ig)in complex with farnesyl pyrophosphate
Structure deposition date
2008-07-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
98
Peptide accession
Q08602
Residue number A
132
Residue number B
145
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 132 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 246 and 260.

Details

Redox score ?
67
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
8
% buried
94
Peptide accession
Q08602
Residue number A
246
Residue number B
260
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 246 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 246 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
94
Peptide accession
Q08602
Residue number A
246
Residue number B
247
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 246 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 331 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
62
Peptide accession
Q08602
Residue number A
331
Residue number B
342
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 331 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 256 and 302. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1dce
Structure name
crystal structure of rab geranylgeranyltransferase from rat brain
Structure deposition date
1999-11-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
85
Peptide accession
Q08602
Residue number A
256
Residue number B
302
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 256 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 302 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 340 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
54
Peptide accession
Q08602
Residue number A
340
Residue number B
342
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 340 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 247 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
70
Peptide accession
Q08602
Residue number A
247
Residue number B
342
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 247 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 516 and 546. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1dce
Structure name
crystal structure of rab geranylgeranyltransferase from rat brain
Structure deposition date
1999-11-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
26
Peptide accession
Q08602
Residue number A
516
Residue number B
546
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 516 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 546 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 247 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
Q08602
Residue number A
247
Residue number B
260
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 247 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 247 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
96
Peptide accession
Q08602
Residue number A
247
Residue number B
487
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 247 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 114 and 132. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3pz2
Structure name
crystal structure of rabggtase(delta lrr; delta ig) in complex with bms3 and lipid substrate ggpp
Structure deposition date
2010-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
100
Peptide accession
Q08602
Residue number A
114
Residue number B
132
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 114 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 247 and 331. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
1dce
Structure name
crystal structure of rab geranylgeranyltransferase from rat brain
Structure deposition date
1999-11-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
93
Peptide accession
Q08602
Residue number A
247
Residue number B
331
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 247 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 331 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 256 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
1dce
Structure name
crystal structure of rab geranylgeranyltransferase from rat brain
Structure deposition date
1999-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
90
Peptide accession
Q08602
Residue number A
256
Residue number B
487
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 256 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit alpha between cysteines 260 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
1dce
Structure name
crystal structure of rab geranylgeranyltransferase from rat brain
Structure deposition date
1999-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
96
Peptide accession
Q08602
Residue number A
260
Residue number B
487
Peptide name
Geranylgeranyl transferase type-2 subunit alpha

Ligandability

Cysteine 260 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Geranylgeranyl transferase type-2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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