ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-type tyrosine-protein phosphatase U

Intramolecular
Cysteine 998 and cysteine 1085
Cysteine 1085 and cysteine 1094
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase U between cysteines 998 and 1085. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6sub
Structure name
human ptpru d1 domain, reduced form
Structure deposition date
2019-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
83
Peptide accession
Q92729
Residue number A
998
Residue number B
1085
Peptide name
Receptor-type tyrosine-protein phosphatase U

Ligandability

Cysteine 998 of Receptor-type tyrosine-protein phosphatase U

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1085 of Receptor-type tyrosine-protein phosphatase U

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase U between cysteines 1085 and 1094. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6sub
Structure name
human ptpru d1 domain, reduced form
Structure deposition date
2019-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
100
Peptide accession
Q92729
Residue number A
1085
Residue number B
1094
Peptide name
Receptor-type tyrosine-protein phosphatase U

Ligandability

Cysteine 1085 of Receptor-type tyrosine-protein phosphatase U

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1094 of Receptor-type tyrosine-protein phosphatase U

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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