Cyclin-dependent kinase-like 2
Intramolecular
Cysteine 21 and cysteine 70
Cysteine 267 and cysteine 278
Cysteine 117 and cysteine 278
Cysteine 190 and cysteine 267
Cysteine 190 and cysteine 217
4bbm B 21 B 70
A redox-regulated disulphide may form within Cyclin-dependent kinase-like 2 between cysteines 21 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4bbm
Structure name
crystal structure of the human cdkl2 kinase domain with bound tcs 2312
Structure deposition date
2012-09-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
12
Peptide accession
Q92772
Residue number A
21
Residue number B
70
Peptide name
Cyclin-dependent kinase-like 2
Ligandability
Cysteine 21 of Cyclin-dependent kinase-like 2
Cysteine 70 of Cyclin-dependent kinase-like 2
4bbm B 267 B 278
A redox-regulated disulphide may form within Cyclin-dependent kinase-like 2 between cysteines 267 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4bbm
Structure name
crystal structure of the human cdkl2 kinase domain with bound tcs 2312
Structure deposition date
2012-09-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
98
Peptide accession
Q92772
Residue number A
267
Residue number B
278
Peptide name
Cyclin-dependent kinase-like 2
Ligandability
Cysteine 267 of Cyclin-dependent kinase-like 2
Cysteine 278 of Cyclin-dependent kinase-like 2
4bbm B 117 B 278
A redox-regulated disulphide may form within Cyclin-dependent kinase-like 2 between cysteines 117 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
4bbm
Structure name
crystal structure of the human cdkl2 kinase domain with bound tcs 2312
Structure deposition date
2012-09-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
88
Peptide accession
Q92772
Residue number A
117
Residue number B
278
Peptide name
Cyclin-dependent kinase-like 2
Ligandability
Cysteine 117 of Cyclin-dependent kinase-like 2
Cysteine 278 of Cyclin-dependent kinase-like 2
4aaa A 190 A 267
A redox-regulated disulphide may form within Cyclin-dependent kinase-like 2 between cysteines 190 and 267. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
4aaa
Structure name
crystal structure of the human cdkl2 kinase domain
Structure deposition date
2011-11-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
Q92772
Residue number A
190
Residue number B
267
Peptide name
Cyclin-dependent kinase-like 2
Ligandability
Cysteine 190 of Cyclin-dependent kinase-like 2
Cysteine 267 of Cyclin-dependent kinase-like 2
4aaa A 190 A 217
A redox-regulated disulphide may form within Cyclin-dependent kinase-like 2 between cysteines 190 and 217. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
4aaa
Structure name
crystal structure of the human cdkl2 kinase domain
Structure deposition date
2011-11-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
88
Peptide accession
Q92772
Residue number A
190
Residue number B
217
Peptide name
Cyclin-dependent kinase-like 2
Ligandability
Cysteine 190 of Cyclin-dependent kinase-like 2
Cysteine 217 of Cyclin-dependent kinase-like 2
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