CREB-binding protein
Intramolecular
Cysteine 1808 and cysteine 1816
Cysteine 1833 and cysteine 1838
Cysteine 380 and cysteine 398
Cysteine 397 and cysteine 403
Cysteine 1785 and cysteine 1790 L
Cysteine 1809 and cysteine 1820
Cysteine 1213 and cysteine 1219 L
Cysteine 1283 and cysteine 1311
Cysteine 1834 and cysteine 1844
Cysteine 1283 and cysteine 1286
More...Cysteine 1237 and cysteine 1240
Cysteine 379 and cysteine 384
Cysteine 1283 and cysteine 1308
Cysteine 421 and cysteine 426 L
Cysteine 1213 and cysteine 1237
Cysteine 1708 and cysteine 1711
Cysteine 397 and cysteine 408
Cysteine 1213 and cysteine 1240
Cysteine 1286 and cysteine 1311
Cysteine 1785 and cysteine 1795 L
Cysteine 1708 and cysteine 1733
Cysteine 1199 and cysteine 1294
Cysteine 366 and cysteine 379
Cysteine 1721 and cysteine 1724
Cysteine 1219 and cysteine 1237 L
Cysteine 1838 and cysteine 1843
Cysteine 426 and cysteine 429 L
Cysteine 1730 and cysteine 1733
Cysteine 1708 and cysteine 1730
Cysteine 1286 and cysteine 1308
Cysteine 1308 and cysteine 1311
Cysteine 403 and cysteine 408
Cysteine 1817 and cysteine 1820
Cysteine 385 and cysteine 398
Cysteine 1790 and cysteine 1795
Cysteine 1710 and cysteine 1729
Cysteine 421 and cysteine 429 L
Cysteine 1710 and cysteine 1732
Cysteine 366 and cysteine 384
Cysteine 1199 and cysteine 1200
2kje A 1809 A 1817
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1808 and 1816 (1809 and 1817 respectively in this structure).
Details
Redox score ?
91
PDB code
2kje
Structure name
nmr structure of cbp taz2 and adenoviral e1a complex
Structure deposition date
2009-05-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
5
% buried
0
Peptide accession
Q92793
Residue number A
1808
Residue number B
1816
Peptide name
CREB-binding protein
Ligandability
Cysteine 1808 of CREB-binding protein
Cysteine 1816 of CREB-binding protein
2kje A 1834 A 1839
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1833 and 1838 (1834 and 1839 respectively in this structure).
Details
Redox score ?
91
PDB code
2kje
Structure name
nmr structure of cbp taz2 and adenoviral e1a complex
Structure deposition date
2009-05-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
11
Peptide accession
Q92793
Residue number A
1833
Residue number B
1838
Peptide name
CREB-binding protein
Ligandability
Cysteine 1833 of CREB-binding protein
Cysteine 1838 of CREB-binding protein
1liq A 5 A 23
A redox-regulated disulphide may form within CREB-binding protein between cysteines 380 and 398 (5 and 23 respectively in this structure).
Details
Redox score ?
91
PDB code
1liq
Structure name
non-native solution structure of a fragment of the ch1 domain of cbp
Structure deposition date
2002-04-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
0
Peptide accession
Q92793
Residue number A
380
Residue number B
398
Peptide name
CREB-binding protein
Ligandability
Cysteine 380 of CREB-binding protein
Cysteine 398 of CREB-binding protein
7lvs B 397 B 403
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 397 and 403.
Details
Redox score ?
90
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
4
Peptide accession
P45481
Residue number A
397
Residue number B
403
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 397 of Histone lysine acetyltransferase CREBBP
Cysteine 403 of Histone lysine acetyltransferase CREBBP
2kje A 1786 A 1791
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1785 and 1790 (1786 and 1791 respectively in this structure).
Details
Redox score ?
89
PDB code
2kje
Structure name
nmr structure of cbp taz2 and adenoviral e1a complex
Structure deposition date
2009-05-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
7
% buried
0
Peptide accession
Q92793
Residue number A
1785
Residue number B
1790
Peptide name
CREB-binding protein
Ligandability
Cysteine 1785 of CREB-binding protein
Cysteine 1790 of CREB-binding protein
2ka6 A 46 A 57
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1809 and 1820 (46 and 57 respectively in this structure).
Details
Redox score ?
89
PDB code
2ka6
Structure name
nmr structure of the cbp-taz2/stat1-tad complex
Structure deposition date
2008-10-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
5
% buried
24
Peptide accession
P45481
Residue number A
1809
Residue number B
1820
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1809 of Histone lysine acetyltransferase CREBBP
Cysteine 1820 of Histone lysine acetyltransferase CREBBP
5i8b A 1213 A 1219
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1213 and 1219.
Details
Redox score ?
89
PDB code
5i8b
Structure name
cbp in complex with cpd23 ((r)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4, 5-tetrahydro-2h-benzo[b][1,4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
6
Peptide accession
Q92793
Residue number A
1213
Residue number B
1219
Peptide name
CREB-binding protein
Ligandability
Cysteine 1213 of CREB-binding protein
Cysteine 1219 of CREB-binding protein
4n4f A 1283 A 1311
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1283 and 1311.
Details
Redox score ?
88
PDB code
4n4f
Structure name
crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac)
Structure deposition date
2013-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
9
Peptide accession
Q92793
Residue number A
1283
Residue number B
1311
Peptide name
CREB-binding protein
Ligandability
Cysteine 1283 of CREB-binding protein
Cysteine 1311 of CREB-binding protein
2ka6 A 71 A 81
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1834 and 1844 (71 and 81 respectively in this structure).
Details
Redox score ?
88
PDB code
2ka6
Structure name
nmr structure of the cbp-taz2/stat1-tad complex
Structure deposition date
2008-10-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
24
Peptide accession
P45481
Residue number A
1834
Residue number B
1844
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1834 of Histone lysine acetyltransferase CREBBP
Cysteine 1844 of Histone lysine acetyltransferase CREBBP
6alb A 1283 A 1286
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1283 and 1286.
Details
Redox score ?
88
PDB code
6alb
Structure name
crebbp bromodomain in complex with cpd 30 (1-(3-(3-(1-methyl-1h- pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2h-pyran-4-yl)-1,4,6,7- tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Structure deposition date
2017-08-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
5
% buried
24
Peptide accession
Q92793
Residue number A
1283
Residue number B
1286
Peptide name
CREB-binding protein
Ligandability
Cysteine 1283 of CREB-binding protein
Cysteine 1286 of CREB-binding protein
5i8g A 1237 A 1240
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1237 and 1240.
Details
Redox score ?
87
PDB code
5i8g
Structure name
cbp in complex with cpd637 ((r)-4-methyl-6-(1-methyl-3-(1-methyl-1h- pyrazol-4-yl)-1h-indazol-5-yl)-1,3,4,5-tetrahydro-2h-benzo[b][1, 4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
0
Peptide accession
Q92793
Residue number A
1237
Residue number B
1240
Peptide name
CREB-binding protein
Ligandability
Cysteine 1237 of CREB-binding protein
Cysteine 1240 of CREB-binding protein
7lvs B 379 B 384
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 379 and 384.
Details
Redox score ?
85
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
39
Peptide accession
P45481
Residue number A
379
Residue number B
384
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 379 of Histone lysine acetyltransferase CREBBP
Cysteine 384 of Histone lysine acetyltransferase CREBBP
5i8b A 1283 A 1308
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1283 and 1308.
Details
Redox score ?
85
PDB code
5i8b
Structure name
cbp in complex with cpd23 ((r)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4, 5-tetrahydro-2h-benzo[b][1,4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
29
Peptide accession
Q92793
Residue number A
1283
Residue number B
1308
Peptide name
CREB-binding protein
Ligandability
Cysteine 1283 of CREB-binding protein
Cysteine 1308 of CREB-binding protein
7lvs B 421 B 426
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 421 and 426.
Details
Redox score ?
85
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
7
% buried
33
Peptide accession
P45481
Residue number A
421
Residue number B
426
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 421 of Histone lysine acetyltransferase CREBBP
Cysteine 426 of Histone lysine acetyltransferase CREBBP
5i8b A 1213 A 1237
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1213 and 1237.
Details
Redox score ?
84
PDB code
5i8b
Structure name
cbp in complex with cpd23 ((r)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4, 5-tetrahydro-2h-benzo[b][1,4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
6
Peptide accession
Q92793
Residue number A
1213
Residue number B
1237
Peptide name
CREB-binding protein
Ligandability
Cysteine 1213 of CREB-binding protein
Cysteine 1237 of CREB-binding protein
1tot A 9 A 12
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1708 and 1711 (9 and 12 respectively in this structure).
Details
Redox score ?
84
PDB code
1tot
Structure name
zz domain of cbp- a novel fold for a protein interaction module
Structure deposition date
2004-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
12
Peptide accession
P45481
Residue number A
1708
Residue number B
1711
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1708 of Histone lysine acetyltransferase CREBBP
Cysteine 1711 of Histone lysine acetyltransferase CREBBP
7lvs B 397 B 408
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 397 and 408.
Details
Redox score ?
84
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
22
Peptide accession
P45481
Residue number A
397
Residue number B
408
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 397 of Histone lysine acetyltransferase CREBBP
Cysteine 408 of Histone lysine acetyltransferase CREBBP
6alb A 1213 A 1240
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1213 and 1240.
Details
Redox score ?
84
PDB code
6alb
Structure name
crebbp bromodomain in complex with cpd 30 (1-(3-(3-(1-methyl-1h- pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2h-pyran-4-yl)-1,4,6,7- tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Structure deposition date
2017-08-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
0
Peptide accession
Q92793
Residue number A
1213
Residue number B
1240
Peptide name
CREB-binding protein
Ligandability
Cysteine 1213 of CREB-binding protein
Cysteine 1240 of CREB-binding protein
5i8b A 1286 A 1311
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1286 and 1311.
Details
Redox score ?
84
PDB code
5i8b
Structure name
cbp in complex with cpd23 ((r)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4, 5-tetrahydro-2h-benzo[b][1,4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
17
Peptide accession
Q92793
Residue number A
1286
Residue number B
1311
Peptide name
CREB-binding protein
Ligandability
Cysteine 1286 of CREB-binding protein
Cysteine 1311 of CREB-binding protein
2kje A 1786 A 1796
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1785 and 1795 (1786 and 1796 respectively in this structure).
Details
Redox score ?
83
PDB code
2kje
Structure name
nmr structure of cbp taz2 and adenoviral e1a complex
Structure deposition date
2009-05-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
12
Peptide accession
Q92793
Residue number A
1785
Residue number B
1795
Peptide name
CREB-binding protein
Ligandability
Cysteine 1785 of CREB-binding protein
Cysteine 1795 of CREB-binding protein
1tot A 9 A 34
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1708 and 1733 (9 and 34 respectively in this structure).
Details
Redox score ?
83
PDB code
1tot
Structure name
zz domain of cbp- a novel fold for a protein interaction module
Structure deposition date
2004-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
12
Peptide accession
P45481
Residue number A
1708
Residue number B
1733
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1708 of Histone lysine acetyltransferase CREBBP
Cysteine 1733 of Histone lysine acetyltransferase CREBBP
4n4f A 1199 A 1294
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1199 and 1294.
Details
Redox score ?
83
PDB code
4n4f
Structure name
crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac)
Structure deposition date
2013-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
4
% buried
48
Peptide accession
Q92793
Residue number A
1199
Residue number B
1294
Peptide name
CREB-binding protein
Ligandability
Cysteine 1199 of CREB-binding protein
Cysteine 1294 of CREB-binding protein
7lvs B 366 B 379
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 366 and 379.
Details
Redox score ?
83
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
7
% buried
32
Peptide accession
P45481
Residue number A
366
Residue number B
379
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 366 of Histone lysine acetyltransferase CREBBP
Cysteine 379 of Histone lysine acetyltransferase CREBBP
1tot A 22 A 25
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1721 and 1724 (22 and 25 respectively in this structure).
Details
Redox score ?
82
PDB code
1tot
Structure name
zz domain of cbp- a novel fold for a protein interaction module
Structure deposition date
2004-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
5
Peptide accession
P45481
Residue number A
1721
Residue number B
1724
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1721 of Histone lysine acetyltransferase CREBBP
Cysteine 1724 of Histone lysine acetyltransferase CREBBP
5i8b A 1219 A 1237
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1219 and 1237.
Details
Redox score ?
82
PDB code
5i8b
Structure name
cbp in complex with cpd23 ((r)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4, 5-tetrahydro-2h-benzo[b][1,4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
0
Peptide accession
Q92793
Residue number A
1219
Residue number B
1237
Peptide name
CREB-binding protein
Ligandability
Cysteine 1219 of CREB-binding protein
Cysteine 1237 of CREB-binding protein
2kje A 1839 A 1844
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1838 and 1843 (1839 and 1844 respectively in this structure).
Details
Redox score ?
82
PDB code
2kje
Structure name
nmr structure of cbp taz2 and adenoviral e1a complex
Structure deposition date
2009-05-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
18
Peptide accession
Q92793
Residue number A
1838
Residue number B
1843
Peptide name
CREB-binding protein
Ligandability
Cysteine 1838 of CREB-binding protein
Cysteine 1843 of CREB-binding protein
7lvs B 426 B 429
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 426 and 429.
Details
Redox score ?
82
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
52
Peptide accession
P45481
Residue number A
426
Residue number B
429
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 426 of Histone lysine acetyltransferase CREBBP
Cysteine 429 of Histone lysine acetyltransferase CREBBP
1tot A 31 A 34
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1730 and 1733 (31 and 34 respectively in this structure).
Details
Redox score ?
81
PDB code
1tot
Structure name
zz domain of cbp- a novel fold for a protein interaction module
Structure deposition date
2004-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
7
Peptide accession
P45481
Residue number A
1730
Residue number B
1733
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1730 of Histone lysine acetyltransferase CREBBP
Cysteine 1733 of Histone lysine acetyltransferase CREBBP
1tot A 9 A 31
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1708 and 1730 (9 and 31 respectively in this structure).
Details
Redox score ?
81
PDB code
1tot
Structure name
zz domain of cbp- a novel fold for a protein interaction module
Structure deposition date
2004-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
6
% buried
20
Peptide accession
P45481
Residue number A
1708
Residue number B
1730
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1708 of Histone lysine acetyltransferase CREBBP
Cysteine 1730 of Histone lysine acetyltransferase CREBBP
6alb A 1286 A 1308
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1286 and 1308.
Details
Redox score ?
81
PDB code
6alb
Structure name
crebbp bromodomain in complex with cpd 30 (1-(3-(3-(1-methyl-1h- pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2h-pyran-4-yl)-1,4,6,7- tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Structure deposition date
2017-08-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
28
Peptide accession
Q92793
Residue number A
1286
Residue number B
1308
Peptide name
CREB-binding protein
Ligandability
Cysteine 1286 of CREB-binding protein
Cysteine 1308 of CREB-binding protein
5i8g A 1308 A 1311
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1308 and 1311.
Details
Redox score ?
81
PDB code
5i8g
Structure name
cbp in complex with cpd637 ((r)-4-methyl-6-(1-methyl-3-(1-methyl-1h- pyrazol-4-yl)-1h-indazol-5-yl)-1,3,4,5-tetrahydro-2h-benzo[b][1, 4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
10
% buried
17
Peptide accession
Q92793
Residue number A
1308
Residue number B
1311
Peptide name
CREB-binding protein
Ligandability
Cysteine 1308 of CREB-binding protein
Cysteine 1311 of CREB-binding protein
7lvs B 403 B 408
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 403 and 408.
Details
Redox score ?
81
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
18
Peptide accession
P45481
Residue number A
403
Residue number B
408
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 403 of Histone lysine acetyltransferase CREBBP
Cysteine 408 of Histone lysine acetyltransferase CREBBP
2ka6 A 54 A 57
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 1817 and 1820 (54 and 57 respectively in this structure).
Details
Redox score ?
81
PDB code
2ka6
Structure name
nmr structure of the cbp-taz2/stat1-tad complex
Structure deposition date
2008-10-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
32
Peptide accession
P45481
Residue number A
1817
Residue number B
1820
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 1817 of Histone lysine acetyltransferase CREBBP
Cysteine 1820 of Histone lysine acetyltransferase CREBBP
1wo5 A 10 A 23
A redox-regulated disulphide may form within CREB-binding protein between cysteines 385 and 398 (10 and 23 respectively in this structure).
Details
Redox score ?
80
PDB code
1wo5
Structure name
solution structure of designed functional finger 2 (dff2): designed mutant based on non-native chance domain
Structure deposition date
2004-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
10
% buried
0
Peptide accession
Q92793
Residue number A
385
Residue number B
398
Peptide name
CREB-binding protein
Ligandability
Cysteine 385 of CREB-binding protein
Cysteine 398 of CREB-binding protein
2kje A 1791 A 1796
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1790 and 1795 (1791 and 1796 respectively in this structure).
Details
Redox score ?
80
PDB code
2kje
Structure name
nmr structure of cbp taz2 and adenoviral e1a complex
Structure deposition date
2009-05-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
12
Peptide accession
Q92793
Residue number A
1790
Residue number B
1795
Peptide name
CREB-binding protein
Ligandability
Cysteine 1790 of CREB-binding protein
Cysteine 1795 of CREB-binding protein
2n1a B 212 B 231
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1710 and 1729 (212 and 231 respectively in this structure).
Details
Redox score ?
80
PDB code
2n1a
Structure name
docked structure between sumo1 and zz-domain from cbp
Structure deposition date
2015-03-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
16
Peptide accession
Q92793
Residue number A
1710
Residue number B
1729
Peptide name
CREB-binding protein
Ligandability
Cysteine 1710 of CREB-binding protein
Cysteine 1729 of CREB-binding protein
7lvs B 421 B 429
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 421 and 429.
Details
Redox score ?
77
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
48
Peptide accession
P45481
Residue number A
421
Residue number B
429
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 421 of Histone lysine acetyltransferase CREBBP
Cysteine 429 of Histone lysine acetyltransferase CREBBP
2n1a B 212 B 234
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1710 and 1732 (212 and 234 respectively in this structure).
Details
Redox score ?
75
PDB code
2n1a
Structure name
docked structure between sumo1 and zz-domain from cbp
Structure deposition date
2015-03-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
13
Peptide accession
Q92793
Residue number A
1710
Residue number B
1732
Peptide name
CREB-binding protein
Ligandability
Cysteine 1710 of CREB-binding protein
Cysteine 1732 of CREB-binding protein
7lvs B 366 B 384
A redox-regulated disulphide may form within Histone lysine acetyltransferase CREBBP between cysteines 366 and 384.
Details
Redox score ?
75
PDB code
7lvs
Structure name
the cbp taz1 domain in complex with a cited2-hif-1-alpha fusion peptide
Structure deposition date
2021-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
44
Peptide accession
P45481
Residue number A
366
Residue number B
384
Peptide name
Histone lysine acetyltransferase CREBBP
Ligandability
Cysteine 366 of Histone lysine acetyltransferase CREBBP
Cysteine 384 of Histone lysine acetyltransferase CREBBP
5i8b A 1199 A 1200
A redox-regulated disulphide may form within CREB-binding protein between cysteines 1199 and 1200.
Details
Redox score ?
74
PDB code
5i8b
Structure name
cbp in complex with cpd23 ((r)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4, 5-tetrahydro-2h-benzo[b][1,4]diazepin-2-one)
Structure deposition date
2016-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
57
Peptide accession
Q92793
Residue number A
1199
Residue number B
1200
Peptide name
CREB-binding protein
Ligandability
Cysteine 1199 of CREB-binding protein
Cysteine 1200 of CREB-binding protein
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