Histone acetyltransferase KAT2A
Intramolecular
Cysteine 113 and cysteine 145
Cysteine 107 and cysteine 113
Cysteine 115 and cysteine 142
Cysteine 142 and cysteine 145
Cysteine 113 and cysteine 115
Cysteine 115 and cysteine 145
Cysteine 107 and cysteine 145
Cysteine 804 and cysteine 815
Cysteine 113 and cysteine 142
Cysteine 107 and cysteine 142
More...Cysteine 107 and cysteine 115
Cysteine 815 and cysteine 817
Cysteine 804 and cysteine 817
Cysteine 564 and cysteine 579
Cysteine 292 and cysteine 294
7by1 A 113 A 145
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 113 and 145.
Details
Redox score ?
89
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
6
% buried
4
Peptide accession
Q9JHD2
Residue number A
113
Residue number B
145
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 113 of Histone acetyltransferase KAT2A
Cysteine 145 of Histone acetyltransferase KAT2A
7by1 A 107 A 113
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 107 and 113.
Details
Redox score ?
88
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
6
Peptide accession
Q9JHD2
Residue number A
107
Residue number B
113
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 107 of Histone acetyltransferase KAT2A
Cysteine 113 of Histone acetyltransferase KAT2A
7by1 A 115 A 142
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 115 and 142.
Details
Redox score ?
87
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
21
Peptide accession
Q9JHD2
Residue number A
115
Residue number B
142
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 115 of Histone acetyltransferase KAT2A
Cysteine 142 of Histone acetyltransferase KAT2A
7by1 B 142 B 145
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 142 and 145.
Details
Redox score ?
86
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
15
Peptide accession
Q9JHD2
Residue number A
142
Residue number B
145
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 142 of Histone acetyltransferase KAT2A
Cysteine 145 of Histone acetyltransferase KAT2A
7by1 A 113 A 115
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 113 and 115.
Details
Redox score ?
81
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
10
Peptide accession
Q9JHD2
Residue number A
113
Residue number B
115
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 113 of Histone acetyltransferase KAT2A
Cysteine 115 of Histone acetyltransferase KAT2A
7by1 B 115 B 145
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 115 and 145.
Details
Redox score ?
79
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
14
Peptide accession
Q9JHD2
Residue number A
115
Residue number B
145
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 115 of Histone acetyltransferase KAT2A
Cysteine 145 of Histone acetyltransferase KAT2A
7by1 A 107 A 145
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 107 and 145.
Details
Redox score ?
79
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
10
Peptide accession
Q9JHD2
Residue number A
107
Residue number B
145
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 107 of Histone acetyltransferase KAT2A
Cysteine 145 of Histone acetyltransferase KAT2A
3d7c B 804 B 815
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 804 and 815.
Details
Redox score ?
76
PDB code
3d7c
Structure name
crystal structure of the bromodomain of human gcn5, the general control of amino-acid synthesis protein 5-like 2
Structure deposition date
2008-05-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
69
Peptide accession
Q92830
Residue number A
804
Residue number B
815
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 804 of Histone acetyltransferase KAT2A
Cysteine 815 of Histone acetyltransferase KAT2A
7by1 B 113 B 142
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 113 and 142.
Details
Redox score ?
71
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
11
Peptide accession
Q9JHD2
Residue number A
113
Residue number B
142
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 113 of Histone acetyltransferase KAT2A
Cysteine 142 of Histone acetyltransferase KAT2A
7by1 A 107 A 142
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 107 and 142.
Details
Redox score ?
69
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
18
Peptide accession
Q9JHD2
Residue number A
107
Residue number B
142
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 107 of Histone acetyltransferase KAT2A
Cysteine 142 of Histone acetyltransferase KAT2A
7by1 A 107 A 115
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 107 and 115.
Details
Redox score ?
68
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
16
Peptide accession
Q9JHD2
Residue number A
107
Residue number B
115
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 107 of Histone acetyltransferase KAT2A
Cysteine 115 of Histone acetyltransferase KAT2A
3d7c B 815 B 817
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 815 and 817. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3d7c
Structure name
crystal structure of the bromodomain of human gcn5, the general control of amino-acid synthesis protein 5-like 2
Structure deposition date
2008-05-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
49
Peptide accession
Q92830
Residue number A
815
Residue number B
817
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 815 of Histone acetyltransferase KAT2A
Cysteine 817 of Histone acetyltransferase KAT2A
6j3p B 804 B 817
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 804 and 817. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6j3p
Structure name
crystal structure of the human gcn5 bromodomain in complex with compound (r,r)-36n
Structure deposition date
2019-01-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
64
Peptide accession
Q92830
Residue number A
804
Residue number B
817
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 804 of Histone acetyltransferase KAT2A
Cysteine 817 of Histone acetyltransferase KAT2A
5trm Q 564 Q 579
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 564 and 579. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
5trm
Structure name
crystal structure of human gcn5 histone acetyltransferase domain
Structure deposition date
2016-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q92830
Residue number A
564
Residue number B
579
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 564 of Histone acetyltransferase KAT2A
Cysteine 579 of Histone acetyltransferase KAT2A
7by1 B 292 B 294
A redox-regulated disulphide may form within Histone acetyltransferase KAT2A between cysteines 292 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
7by1
Structure name
crystal structure of gcn5 pcaf n-terminal domain
Structure deposition date
2020-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
94
Peptide accession
Q9JHD2
Residue number A
292
Residue number B
294
Peptide name
Histone acetyltransferase KAT2A
Ligandability
Cysteine 292 of Histone acetyltransferase KAT2A
Cysteine 294 of Histone acetyltransferase KAT2A
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