ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Histone acetyltransferase KAT2B

Intramolecular
Cysteine 799 and cysteine 812
Cysteine 559 and cysteine 574
A redox-regulated disulphide may form within Histone acetyltransferase KAT2B between cysteines 799 and 812. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5lvr
Structure name
crystal structure of human pcaf bromodomain in complex with compound-e (cpd-e)
Structure deposition date
2016-09-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
62
Peptide accession
Q92831
Residue number A
799
Residue number B
812
Peptide name
Histone acetyltransferase KAT2B

Ligandability

Cysteine 799 of Histone acetyltransferase KAT2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 812 of Histone acetyltransferase KAT2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Histone acetyltransferase KAT2B between cysteines 559 and 574. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
1cm0
Structure name
crystal structure of the pcaf/coenzyme-a complex
Structure deposition date
1999-05-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
Q92831
Residue number A
559
Residue number B
574
Peptide name
Histone acetyltransferase KAT2B

Ligandability

Cysteine 559 of Histone acetyltransferase KAT2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 574 of Histone acetyltransferase KAT2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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