ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Probable ATP-dependent RNA helicase DDX17

Intramolecular
Cysteine 431 and cysteine 447
Cysteine 247 and cysteine 319
Cysteine 277 and cysteine 298 L
Cysteine 298 and cysteine 319
Cysteine 247 and cysteine 298
A redox-regulated disulphide may form within Probable ATP-dependent RNA helicase DDX17 between cysteines 431 and 447 (352 and 368 respectively in this structure).

Details

Redox score ?
80
PDB code
6uv1
Structure name
crystal structure of rna helicase ddx17 in complex of ru10 rna
Structure deposition date
2019-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
5
% buried
86
Peptide accession
Q92841
Residue number A
431
Residue number B
447
Peptide name
Probable ATP-dependent RNA helicase DDX17

Ligandability

Cysteine 431 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 447 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable ATP-dependent RNA helicase DDX17 between cysteines 247 and 319 (168 and 240 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6uv0
Structure name
crystal structure of apo core domain of rna helicase ddx17
Structure deposition date
2019-11-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
100
Peptide accession
Q92841
Residue number A
247
Residue number B
319
Peptide name
Probable ATP-dependent RNA helicase DDX17

Ligandability

Cysteine 247 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable ATP-dependent RNA helicase DDX17 between cysteines 277 and 298 (198 and 219 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6uv0
Structure name
crystal structure of apo core domain of rna helicase ddx17
Structure deposition date
2019-11-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
78
Peptide accession
Q92841
Residue number A
277
Residue number B
298
Peptide name
Probable ATP-dependent RNA helicase DDX17

Ligandability

Cysteine 277 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable ATP-dependent RNA helicase DDX17 between cysteines 298 and 319 (219 and 240 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6uv4
Structure name
crystal structure of the core domain of rna helicase ddx17 with rna pri-18a-oligo1
Structure deposition date
2019-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q92841
Residue number A
298
Residue number B
319
Peptide name
Probable ATP-dependent RNA helicase DDX17

Ligandability

Cysteine 298 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable ATP-dependent RNA helicase DDX17 between cysteines 247 and 298 (168 and 219 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6uv0
Structure name
crystal structure of apo core domain of rna helicase ddx17
Structure deposition date
2019-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
Q92841
Residue number A
247
Residue number B
298
Peptide name
Probable ATP-dependent RNA helicase DDX17

Ligandability

Cysteine 247 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of Probable ATP-dependent RNA helicase DDX17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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