ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Growth hormone secretagogue receptor type 1

Intramolecular
Cysteine 116 and cysteine 198
Cysteine 95 and cysteine 126
A redox-regulated disulphide may form within Growth hormone secretagogue receptor type 1 between cysteines 116 and 198.

Details

Redox score ?
84
PDB code
6ko5
Structure name
complex structure of ghrelin receptor with fab
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q92847
Residue number A
116
Residue number B
198
Peptide name
Growth hormone secretagogue receptor type 1

Ligandability

Cysteine 116 of Growth hormone secretagogue receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Growth hormone secretagogue receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth hormone secretagogue receptor type 1 between cysteines 95 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7f83
Structure name
crystal structure of a receptor in complex with inverse agonist
Structure deposition date
2021-07-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
86
Peptide accession
Q92847
Residue number A
95
Residue number B
126
Peptide name
Growth hormone secretagogue receptor type 1

Ligandability

Cysteine 95 of Growth hormone secretagogue receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Growth hormone secretagogue receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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