a tool for identifying drug-targetable redox-active disulphides

Phosphomannomutase 1

Intramolecular

Cysteine 16 and cysteine 250

A redox-regulated disulphide may form within Phosphomannomutase 1 between cysteines 16 and 250.

Details

Redox score ?

62

PDB code

Structure name

human alpha-phosphomannomutase 1 with d-mannose 1-phosphate and mg2+ cofactor bound

Structure deposition date

2006-01-26

Thiol separation (Å)

5

Half-sphere exposure sum ?

77

Minimum pK_a ?

9

% buried

91

Peptide accession

Residue number A

16

Residue number B

250

Peptide name

Phosphomannomutase 1

Ligandability

Cysteine 16 of Phosphomannomutase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of Phosphomannomutase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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