ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CUGBP Elav-like family member 1

Intramolecular
Cysteine 119 and cysteine 177
Cysteine 61 and cysteine 62
Cysteine 119 and cysteine 137
A redox-regulated disulphide may form within CUGBP Elav-like family member 1 between cysteines 119 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3nna
Structure name
crystal structure of cugbp1 rrm1/2-rna complex
Structure deposition date
2010-06-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
10
% buried
30
Peptide accession
Q92879
Residue number A
119
Residue number B
177
Peptide name
CUGBP Elav-like family member 1

Ligandability

Cysteine 119 of CUGBP Elav-like family member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of CUGBP Elav-like family member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CUGBP Elav-like family member 1 between cysteines 61 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3nnh
Structure name
crystal structure of the cugbp1 rrm1 with guuguuuuguuu rna
Structure deposition date
2010-06-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
13
% buried
96
Peptide accession
Q92879
Residue number A
61
Residue number B
62
Peptide name
CUGBP Elav-like family member 1

Ligandability

Cysteine 61 of CUGBP Elav-like family member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of CUGBP Elav-like family member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CUGBP Elav-like family member 1 between cysteines 119 and 137. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3nmr
Structure name
crystal structure of cugbp1 rrm1/2-rna complex
Structure deposition date
2010-06-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
48
Peptide accession
Q92879
Residue number A
119
Residue number B
137
Peptide name
CUGBP Elav-like family member 1

Ligandability

Cysteine 119 of CUGBP Elav-like family member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of CUGBP Elav-like family member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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