ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho guanine nucleotide exchange factor 1

Intramolecular
Cysteine 77 and cysteine 78
Cysteine 594 and cysteine 595 L
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 1 between cysteines 77 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1shz
Structure name
crystal structure of the p115rhogef rgrgs domain in a complex with galpha(13):galpha(i1) chimera
Structure deposition date
2004-02-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
82
Peptide accession
Q92888
Residue number A
77
Residue number B
78
Peptide name
Rho guanine nucleotide exchange factor 1

Ligandability

Cysteine 77 of Rho guanine nucleotide exchange factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Rho guanine nucleotide exchange factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 1 between cysteines 594 and 595. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3odw
Structure name
crystal structure of the linker-dh/ph domains of p115-rhogef
Structure deposition date
2010-08-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
68
Peptide accession
Q92888
Residue number A
594
Residue number B
595
Peptide name
Rho guanine nucleotide exchange factor 1

Ligandability

Cysteine 594 of Rho guanine nucleotide exchange factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 595 of Rho guanine nucleotide exchange factor 1

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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