ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA repair endonuclease XPF

Intramolecular
Cysteine 410 and cysteine 417
Cysteine 723 and cysteine 745
A redox-regulated disulphide may form within DNA repair endonuclease XPF between cysteines 410 and 417. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6sxb
Structure name
xpf-ercc1 cryo-em structure, dna-bound form
Structure deposition date
2019-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
53
Peptide accession
Q92889
Residue number A
410
Residue number B
417
Peptide name
DNA repair endonuclease XPF

Ligandability

Cysteine 410 of DNA repair endonuclease XPF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 417 of DNA repair endonuclease XPF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA repair endonuclease XPF between cysteines 723 and 745. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6sxa
Structure name
xpf-ercc1 cryo-em structure, apo-form
Structure deposition date
2019-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
76
Peptide accession
Q92889
Residue number A
723
Residue number B
745
Peptide name
DNA repair endonuclease XPF

Ligandability

Cysteine 723 of DNA repair endonuclease XPF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 745 of DNA repair endonuclease XPF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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