Regulator of nonsense transcripts 1

Structure name

crystal structure of the upf2-interacting domain of nonsense mediated mrna decay factor upf1

Structure deposition date

2006-07-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Regulator of nonsense transcripts 1

Peptide B name

Regulator of nonsense transcripts 1

Peptide A accession

Peptide B accession

Peptide A residue number

237

Peptide B residue number

237

Ligandability

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 137 and 165.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

137

Residue number B

165

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 137 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 165 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 183 and 209.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

183

Residue number B

209

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 183 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 209 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 183 and 213.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

183

Residue number B

213

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 183 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 213 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 183 and 186.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

183

Residue number B

186

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 183 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 186 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 186 and 209.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

186

Residue number B

209

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 186 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 209 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 186 and 213.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

186

Residue number B

213

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 186 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 213 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 188 and 209 (78 and 99 respectively in this structure).

Details

Redox score ?

PDB code

Structure name

crystal structure of the upf2-interacting domain of nonsense mediated mrna decay factor upf1

Structure deposition date

2006-07-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

188

Residue number B

209

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 188 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 209 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 186 and 188 (76 and 78 respectively in this structure).

Details

Redox score ?

PDB code

Structure name

crystal structure of the upf2-interacting domain of nonsense mediated mrna decay factor upf1

Structure deposition date

2006-07-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

186

Residue number B

188

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 186 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 188 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 183 and 188.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

183

Residue number B

188

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 183 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 188 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 209 and 213.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

209

Residue number B

213

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 209 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 213 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 123 and 126.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

123

Residue number B

126

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 123 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 126 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 126 and 145.

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

126

Residue number B

145

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 126 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 145 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 531 and 626 (520 and 615 respectively in this structure).

Details

Redox score ?

PDB code

2gjk

Structure name

structural and functional insights into the human upf1 helicase core

Structure deposition date

2006-03-31

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

531

Residue number B

626

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 531 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 626 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 188 and 213. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

188

Residue number B

213

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 188 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 213 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 628 and 657 (617 and 646 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2gk7

Structure name

structural and functional insights into the human upf1 helicase core

Structure deposition date

2006-03-31

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

628

Residue number B

657

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 628 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 657 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 123 and 145 (13 and 35 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of the upf2-interacting domain of nonsense mediated mrna decay factor upf1

Structure deposition date

2006-07-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

123

Residue number B

145

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 123 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 145 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 531 and 628. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6ej5

Structure name

a conserved structural element in the rna helicase upf1 regulates its catalytic activity in an isoform-specific manner

Structure deposition date

2017-09-20

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

531

Residue number B

628

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 531 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 628 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 626 and 628 (615 and 617 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2wjy

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2 orthorhombic form

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

626

Residue number B

628

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 626 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 628 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 625 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6ej5

Structure name

a conserved structural element in the rna helicase upf1 regulates its catalytic activity in an isoform-specific manner

Structure deposition date

2017-09-20

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

625

Residue number B

626

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 625 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 626 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 133 and 145 (23 and 35 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of the upf2-interacting domain of nonsense mediated mrna decay factor upf1

Structure deposition date

2006-07-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

133

Residue number B

145

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 133 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 145 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 531 and 657 (520 and 646 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

531

Residue number B

657

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 531 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 657 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 556 and 626 (545 and 615 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

556

Residue number B

626

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 556 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 626 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 126 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2wjy

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2 orthorhombic form

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

126

Residue number B

133

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 126 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 133 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Regulator of nonsense transcripts 1 between cysteines 145 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2

Structure deposition date

2009-06-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

145

Residue number B

237

Peptide name

Regulator of nonsense transcripts 1

Ligandability

Cysteine 145 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.

Cysteine 237 of Regulator of nonsense transcripts 1

Not ligandable in the dataset of Vinogradova et al.