a tool for identifying drug-targetable redox-active disulphides

COP9 signalosome complex subunit 5

Intermolecular

Cysteine 308 and cysteine 299 of COP9 signalosome complex subunit 6 L

A redox-regulated disulphide may form between cysteine 308 of COP9 signalosome complex subunit 5 and cysteine 299 of COP9 signalosome complex subunit 6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

28

PDB code

Structure name

structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome

Structure deposition date

2019-03-28

Thiol separation (Å)

10

Half-sphere exposure sum ?

79

Minimum pK_a ?

11

% buried

98

Peptide A name

COP9 signalosome complex subunit 5

Peptide B name

COP9 signalosome complex subunit 6

Peptide A accession

Peptide B accession

Peptide A residue number

308

Peptide B residue number

299

Ligandability

Cysteine 308 of COP9 signalosome complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of COP9 signalosome complex subunit 6

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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