ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-type tyrosine-protein phosphatase N2

Intermolecular
Cysteine 882 and cysteine 882
Intramolecular
Cysteine 839 and cysteine 939
Cysteine 856 and cysteine 945
Cysteine 839 and cysteine 933
Cysteine 933 and cysteine 939
A redox-regulated disulphide may form between two units of Receptor-type tyrosine-protein phosphatase N2 at cysteines 882 and 882. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2qep
Structure name
crystal structure of the d1 domain of ptprn2 (ia2beta)
Structure deposition date
2007-06-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
50
Peptide A name
Receptor-type tyrosine-protein phosphatase N2
Peptide B name
Receptor-type tyrosine-protein phosphatase N2
Peptide A accession
Q92932
Peptide B accession
Q92932
Peptide A residue number
882
Peptide B residue number
882

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase N2 between cysteines 839 and 939. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2qep
Structure name
crystal structure of the d1 domain of ptprn2 (ia2beta)
Structure deposition date
2007-06-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
66
Peptide accession
Q92932
Residue number A
839
Residue number B
939
Peptide name
Receptor-type tyrosine-protein phosphatase N2

Ligandability

Cysteine 839 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 939 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase N2 between cysteines 856 and 945. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2qep
Structure name
crystal structure of the d1 domain of ptprn2 (ia2beta)
Structure deposition date
2007-06-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
10
% buried
98
Peptide accession
Q92932
Residue number A
856
Residue number B
945
Peptide name
Receptor-type tyrosine-protein phosphatase N2

Ligandability

Cysteine 856 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 945 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase N2 between cysteines 839 and 933. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2qep
Structure name
crystal structure of the d1 domain of ptprn2 (ia2beta)
Structure deposition date
2007-06-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
72
Peptide accession
Q92932
Residue number A
839
Residue number B
933
Peptide name
Receptor-type tyrosine-protein phosphatase N2

Ligandability

Cysteine 839 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 933 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase N2 between cysteines 933 and 939. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2qep
Structure name
crystal structure of the d1 domain of ptprn2 (ia2beta)
Structure deposition date
2007-06-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
39
Peptide accession
Q92932
Residue number A
933
Residue number B
939
Peptide name
Receptor-type tyrosine-protein phosphatase N2

Ligandability

Cysteine 933 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 939 of Receptor-type tyrosine-protein phosphatase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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