ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glutaryl-CoA dehydrogenase, mitochondrial

Intramolecular
Cysteine 228 and cysteine 232
Cysteine 350 and cysteine 375
A redox-regulated disulphide may form within Glutaryl-CoA dehydrogenase, mitochondrial between cysteines 228 and 232 (184 and 188 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1siq
Structure name
the crystal structure and mechanism of human glutaryl-coa dehydrogenase
Structure deposition date
2004-03-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
25
Peptide accession
Q92947
Residue number A
228
Residue number B
232
Peptide name
Glutaryl-CoA dehydrogenase, mitochondrial

Ligandability

Cysteine 228 of Glutaryl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Glutaryl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutaryl-CoA dehydrogenase, mitochondrial between cysteines 350 and 375 (306 and 331 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2r0m
Structure name
the effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate
Structure deposition date
2007-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
100
Peptide accession
Q92947
Residue number A
350
Residue number B
375
Peptide name
Glutaryl-CoA dehydrogenase, mitochondrial

Ligandability

Cysteine 350 of Glutaryl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Glutaryl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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