ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho guanine nucleotide exchange factor 2

Intramolecular
Cysteine 67 and cysteine 307
Cysteine 282 and cysteine 342
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 2 between cysteines 67 and 307 (67 and 104 respectively in this structure).

Details

Redox score ?
70
PDB code
5wi4
Structure name
crystal structure of dynlt1/tctex-1 in complex with arhgef2
Structure deposition date
2017-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
Q60875
Residue number A
67
Residue number B
307
Peptide name
Rho guanine nucleotide exchange factor 2

Ligandability

Cysteine 67 of Rho guanine nucleotide exchange factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Rho guanine nucleotide exchange factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 2 between cysteines 282 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
8bnt
Structure name
the dh domain of arhgef2 bound to rhoa
Structure deposition date
2022-11-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
76
Peptide accession
Q92974
Residue number A
282
Residue number B
342
Peptide name
Rho guanine nucleotide exchange factor 2

Ligandability

Cysteine 282 of Rho guanine nucleotide exchange factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Rho guanine nucleotide exchange factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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