ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Histone acetyltransferase KAT5

Intramolecular
Cysteine 263 and cysteine 283
Cysteine 263 and cysteine 266
Cysteine 266 and cysteine 283
Cysteine 317 and cysteine 369
A redox-regulated disulphide may form within Histone acetyltransferase KAT5 between cysteines 263 and 283 (211 and 231 respectively in this structure).

Details

Redox score ?
90
PDB code
2ou2
Structure name
acetyltransferase domain of human hiv-1 tat interacting protein, 60kda, isoform 3
Structure deposition date
2007-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
3
% buried
40
Peptide accession
Q92993
Residue number A
263
Residue number B
283
Peptide name
Histone acetyltransferase KAT5

Ligandability

Cysteine 263 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Histone acetyltransferase KAT5 between cysteines 263 and 266 (211 and 214 respectively in this structure).

Details

Redox score ?
83
PDB code
2ou2
Structure name
acetyltransferase domain of human hiv-1 tat interacting protein, 60kda, isoform 3
Structure deposition date
2007-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
3
% buried
52
Peptide accession
Q92993
Residue number A
263
Residue number B
266
Peptide name
Histone acetyltransferase KAT5

Ligandability

Cysteine 263 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Histone acetyltransferase KAT5 between cysteines 266 and 283 (214 and 231 respectively in this structure).

Details

Redox score ?
75
PDB code
2ou2
Structure name
acetyltransferase domain of human hiv-1 tat interacting protein, 60kda, isoform 3
Structure deposition date
2007-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
36
Peptide accession
Q92993
Residue number A
266
Residue number B
283
Peptide name
Histone acetyltransferase KAT5

Ligandability

Cysteine 266 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Histone acetyltransferase KAT5 between cysteines 317 and 369 (265 and 317 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2ou2
Structure name
acetyltransferase domain of human hiv-1 tat interacting protein, 60kda, isoform 3
Structure deposition date
2007-02-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
98
Peptide accession
Q92993
Residue number A
317
Residue number B
369
Peptide name
Histone acetyltransferase KAT5

Ligandability

Cysteine 317 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 369 of Histone acetyltransferase KAT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: